Repository logo
 
Publication

The mRNA Metabolism in Human Disease

2019-08-07Book Restricted access
Simple item page
dc.contributor.editorRomão, Luísa
dc.date.accessioned2020-07-30T16:02:27Z
dc.date.available2020-07-30T16:02:27Z
dc.date.issued2019-08-07
dc.description.abstractIntroduction: The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to the cytoplasm where it is translated into protein and finally degraded. In this process, mRNA is associated with RNA-binding proteins forming ribonucleoprotein complexes, whose protein content evolves throughout the lifetime of the mRNA. While the complexity of eukaryotic gene expression allows the production of proteins to be controlled at many levels, it also makes the process vulnerable to errors. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism. This condition plays a fundamental role in the pathogenesis of several disease processes, such as neurodegeneration and oncogenesis. Besides, exciting recent data have shown that cellular RNAs can be modified post-transcriptionally via dynamic and reversible chemical modifications, the so-called epitranscriptome. These modifications can alter mRNA structure, being able to modulate different steps of the mRNA metabolism that can be associated with various human diseases, such as systemic lupus erythematosus and cancer. This book provides a collection of novel studies and hypotheses aimed to define the pathophysiological consequences of altered mRNA metabolism events in human cells, and is written for a wide spectrum of readers in the field of gene expression regulation. The last chapter highlights how the discovery of disease-causing defects (or modifications) in mRNA can provide a variety of therapeutic targets that can be used for the development of new RNA-based therapeutics. Hopefully, it may also contribute to inspire the drug-developing scientific community.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRomão L (ed). The mRNA Metabolism in Human Disease. Advances in Experimental Medicine and Biology. Springer, Cham., 2019. (AEMB, volume 1157). doi:10.1007/978-3-030-19966-1pt_PT
dc.identifier.doi10.1007/978-3-030-19966-1pt_PT
dc.identifier.issn978-3-030-19966-1
dc.identifier.urihttp://hdl.handle.net/10400.18/7132
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.ispartofseries(AEMB, volume 1157)
dc.relation.publisherversionhttps://link.springer.com/book/10.1007/978-3-030-19966-1pt_PT
dc.subjectmRNA Metabolismpt_PT
dc.subjectGene Expression Regulationpt_PT
dc.subjectHuman Genetic Diseasept_PT
dc.subjectCancerpt_PT
dc.subjectRNA-based Therapeuticspt_PT
dc.subjectTranslatomept_PT
dc.subjectDoenças Genéticaspt_PT
dc.subjectGenómica Funcional e Estruturalpt_PT
dc.titleThe mRNA Metabolism in Human Diseasept_PT
dc.typebook
dspace.entity.typePublication
oaire.citation.endPage185pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleAdvances in Experimental Medicine and Biologypt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typebookpt_PT

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
The mRNA Metabolism in Human Disease Book_2019.pdf
Size:
3.88 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DGH - Livros científicos