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Anchoring HBM4EU data to chemicals risk assessment

2020-11-18Conference object Restricted access
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dc.contributor.authorSilva, Maria João
dc.date.accessioned2021-03-19T15:54:49Z
dc.date.available2021-03-19T15:54:49Z
dc.date.issued2020-11-18
dc.description.abstractA major goal of the European Human Biomonitoring Initiative, HBM4EU, is to coordinate and advance human biomonitoring across Europe and reinforce its application in different regulatory frameworks for chemicals. To illustrate the development of state-of-the-art approaches and the potential of human biomonitoring (HBM) data to refine exposure assessment and, thereby, risk assessment, this presentation will be focused on the work carried out on hexavalent chromium, [Cr(VI)], an important occupational lung carcinogen, which is currently authorized in Europe for several industrial activities. Cr(VI) was considered a priority substance under the HBM4EU Project, indicating the need for generating and analyzing data on human exposure, despite the recently agreed binding limit value for occupational exposure established in the Eu-ropean Union. The anchoring of HBM to risk assessment and management practices will be evidenced through the infor-mation generated from three different studies, namely: i) a critical review on effect biomarkers to link Cr(VI) exposure to health outcomes, ii) a multinational, collaborative study to support management of oc-cupational exposure to Cr(VI), and iii) the development of a case study on co-exposure to Cr (VI), nickel and polycyclic aromatic hydrocarbons, to advance the identification of mixture health effects and to pro-gress towards a more refined risk assessment. These research efforts to integrate HBM into new risk assessment approaches need to be supported by mechanistic knowledge obtained from in vitro/in vivo studies, toxicokinetic data and the development of adverse outcome pathways, as well.pt_PT
dc.description.sponsorshipFunded by the HBM4EU (GA 733032) projects and by FCT/MCTES through national funds (UIDB/00009/2020; UIDP/00009/2020).pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7562
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation733032pt_PT
dc.relationCentre for Toxicogenomics and Human Health
dc.relationCentre for Toxicogenomics and Human Health
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleAnchoring HBM4EU data to chemicals risk assessmentpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00009%2F2020/PT
oaire.citation.conferencePlaceLisboa, Portugal (online)pt_PT
oaire.citation.title3rd HBM-PT Workshop on Human BioMonitoring in Portugal, 18 november 2020pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublicationa438b9d1-8a6a-4c90-a13b-7ccf34071451
relation.isProjectOfPublication8836ec79-2300-487a-97ad-75e98cfabcfa
relation.isProjectOfPublication.latestForDiscovery8836ec79-2300-487a-97ad-75e98cfabcfa

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