Anchoring HBM4EU data to chemicals risk assessment

Silva, Maria João

http://hdl.handle.net/10400.18/7562

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Authors

Silva, Maria João

Abstract(s)

A major goal of the European Human Biomonitoring Initiative, HBM4EU, is to coordinate and advance human biomonitoring across Europe and reinforce its application in different regulatory frameworks for chemicals. To illustrate the development of state-of-the-art approaches and the potential of human biomonitoring (HBM) data to refine exposure assessment and, thereby, risk assessment, this presentation will be focused on the work carried out on hexavalent chromium, [Cr(VI)], an important occupational lung carcinogen, which is currently authorized in Europe for several industrial activities. Cr(VI) was considered a priority substance under the HBM4EU Project, indicating the need for generating and analyzing data on human exposure, despite the recently agreed binding limit value for occupational exposure established in the Eu-ropean Union. The anchoring of HBM to risk assessment and management practices will be evidenced through the infor-mation generated from three different studies, namely: i) a critical review on effect biomarkers to link Cr(VI) exposure to health outcomes, ii) a multinational, collaborative study to support management of oc-cupational exposure to Cr(VI), and iii) the development of a case study on co-exposure to Cr (VI), nickel and polycyclic aromatic hydrocarbons, to advance the identification of mixture health effects and to pro-gress towards a more refined risk assessment. These research efforts to integrate HBM into new risk assessment approaches need to be supported by mechanistic knowledge obtained from in vitro/in vivo studies, toxicokinetic data and the development of adverse outcome pathways, as well.