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Is there a relation between environmental exposure to teratogenic substances during pregnancy and congenital anomalies in the newborn? A pilot study in Portugal

2016-06Conference object Open access
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dc.contributor.authorMachado, Ausenda
dc.contributor.authorBraz, Paula
dc.contributor.authorSantos, Joana
dc.contributor.authorMarques, Inês
dc.contributor.authorDias, Carlos Matias
dc.date.accessioned2016-10-19T12:40:29Z
dc.date.available2016-10-19T12:40:29Z
dc.date.issued2016-06
dc.description.abstractBackground: Maternal occupation as a proxy of environmental exposure has been consistently associated with specific congenital anomalies (CA) in the foetus and newborn. On the other hand, geographical location of the mother such as place of residence and place of work have not been used as proxy for environmental exposures during pregnancy. We designed a pilot study aiming to investigate the association between maternal place of residence and workplace during pregnancy and CA in Portugal. Methods: Cases and controls are identified in the maternity unit. Cases are all live births with at least one CA delivered in the Barreiro hospital located in a heavy industrial area near Lisboa. Controls are the two normal births following each case. Residents outside the study area, stillbirths and women who decline to participate or are incapable of giving consent are excluded. A health professional interviews the mothers using a questionnaire adapted from the registry form of the Portuguese national registry of CA and includes information on places during pregnancy (residence, workplace, leisure), and demographic characterization as place of birth, infant sex, weight, description of CA, age of mother, ethnicity, maternal birth place. Maternal health and obstetric history, education, smoking, alcohol, drugs and medication use is also collected as potential confounders. Results: The pilot study started in January 2016 and at the moment two cases and four controls have been recruited without refusals. The study will continue to be implemented and it is proposed to start in other hospital units during 2016.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/4052
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInstituto Nacional de Saúde Doutor Ricardo Jorge, IPpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectRENACpt_PT
dc.subjectCongenital Anomaliespt_PT
dc.subjectEnvironmental Exposurept_PT
dc.subjectPregnancypt_PT
dc.subjectCase Control Studypt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectAnomalias Congénitaspt_PT
dc.subjectRegisto Nacional de Anomalias Congénitaspt_PT
dc.titleIs there a relation between environmental exposure to teratogenic substances during pregnancy and congenital anomalies in the newborn? A pilot study in Portugalpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceMilão, Itáliapt_PT
oaire.citation.title13th EUROCAT Scientific Symposium, 16-17 June 2016pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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