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Vaccine effectiveness against influenza A in older adults and the effect of chronic conditions: results from the I-MOVE and VEBIS multicentre European hospital case-control studies, 2015/16-2023/24

2025-11-03Artigo científico Acesso aberto
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg17:Parcerias para a Implementação dos Objetivos
dc.contributor.authorRose, Angela Mary Catherine
dc.contributor.authorNicolay, Nathalie
dc.contributor.authorMazagatos, Clara
dc.contributor.authorMartínez-Baz, Iván
dc.contributor.authorLaunay, Odile
dc.contributor.authorDe Mot, Laurane
dc.contributor.authorBella, Antonino
dc.contributor.authorLazar, Mihaela
dc.contributor.authorMachado, Ausenda
dc.contributor.authorKuliešė, Monika
dc.contributor.authorAbela, Stephen
dc.contributor.authorVučina, Vesna Višekruna
dc.contributor.authorvan Gageldonk-Lafeber, Rianne
dc.contributor.authorBino, Silvia
dc.contributor.authorDürrwald, Ralf
dc.contributor.authorParadowska-Stankiewicz, Iwona
dc.contributor.authorHorváth, Judit Krisztina
dc.contributor.authorDuffy, Róisín
dc.contributor.authorHusa, Petr
dc.contributor.authorMcMenamin, Jim
dc.contributor.authorPozo, Francisco
dc.contributor.authorHoward, Jennifer
dc.contributor.authorLatorre-Millán, Miriam
dc.contributor.authorCastilla, Jesús
dc.contributor.authorNguyen, Liem Binh Luong
dc.contributor.authorDauby, Nicolas
dc.contributor.authorRiccardo, Flavia
dc.contributor.authorIvanciuc, Alina
dc.contributor.authorGomez, Verónica
dc.contributor.authorJančorienė, Ligita
dc.contributor.authorXuereb, Gerd
dc.contributor.authorPetrović, Goranka
dc.contributor.authorMarbus, Sierk
dc.contributor.authorVasili, Adela
dc.contributor.authorTolksdorf, Kristin
dc.contributor.authorBogusz, Joanna
dc.contributor.authorOroszi, Beatrix
dc.contributor.authorDomegan, Lisa
dc.contributor.authorSoučková, Lenka
dc.contributor.authorMarsh, Kimberley
dc.contributor.authorBacci, Sabrina
dc.contributor.authorKissling, Esther
dc.contributor.authorI-MOVE & VEBIS Hospital Network teams
dc.date.accessioned2026-01-13T15:26:45Z
dc.date.available2026-01-13T15:26:45Z
dc.date.issued2025-11-03
dc.descriptionThe I-MOVE/I-MOVE+ and VEBIS Hospital Network teams include, for Portugal: Ana Paula Rodrigues, Nuno Verdasca, Licínia Gomes, Daniela Dias, Raquel Guiomar (Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisbon),
dc.description.abstractBackground: The Influenza - Monitoring Vaccine Effectiveness in Europe (I-MOVE/I-MOVE+) and Vaccine Effectiveness, Burden and Impact Studies (VEBIS) hospital networks have conducted seasonal multicentre, test-negative, case-control studies in Europe to measure influenza vaccine effectiveness (IVE) since 2015/16. We measured the effect of chronic conditions on VE of influenza A subtypes among older adults (≥ 65 years) using pooled-season data (2015/16-2023/24). Methods: Hospital teams swabbed patients with severe acute respiratory infection (SARI) within 7 days of symptom onset. Cases were RT-PCR positive for influenza A(H1N1)pdm09 or A(H3N2); controls negative for any influenza virus. We calculated overall pooled-season IVE against influenza A(H1N1)pdm09 and A(H3N2), adjusted for study site, sex, age and onset date; and stratified by number of and by each chronic condition (diabetes, heart disease, lung disease/asthma, immunosuppression, kidney disease, liver disease, cancer, obesity). We investigated interaction between vaccination and each condition. Results: We included 1805 A(H1N1)pdm09 cases with 16,329 controls; 2590 A(H3N2) cases with 14,920 controls, from 13 study sites (12 countries). Over all seasons, 63-67% cases and 70% controls had ≥ 2 chronic conditions. Against A(H1N1)pdm09, pooled-season IVE was 37% (95%CI: 29-44) overall; 49% (95%CI: 9-72), 30% (95%CI: 12-44) and 38% (95%CI: 29-46) in those with 0, 1, ≥ 2 chronic conditions. Most IVE point estimates were 34-45%, apart from immunosuppression (-7%), kidney disease (17%) and liver disease (54%), but 95% CIs overlapped. Significant interaction was observed for kidney disease (p = 0.02) and immunosuppression (p = 0.01). Against A(H3N2), pooled-season IVE was 17% (95%CI: 8-25) overall; 15% (95%CI: -26-42), 11% (95%CI: -8-27) and 18% (95%CI: 7-28) in those with 0, 1, ≥ 2 chronic conditions. Here, IVE point estimates ranged 13-25%, apart from immunosuppression (5%), kidney disease (6%) and liver disease (31%), although 95% CIs overlapped. There were no significant interactions. Conclusions: Pooled-season results suggest low-moderate VE against influenza A subtypes among older SARI patients; higher against A(H1N1)pdm09 than A(H3N2), with little evidence of chronic condition modifying effect, apart from kidney disease and immunosuppression. We stress the importance of developing improved influenza vaccines for specific populations, and encourage further research into the effect of chronic conditions on IVE in older adults.eng
dc.description.sponsorshipFor the I-MOVE+ and I-MOVE-COVID-19 networks, participating hospitals and institutes received funding from the European Commission Horizon 2020 (Grant Agreement Nos 634446 and 101003673), Epiconcept, and the World Health Organization. For the VEBIS network participants, funding was received from the European Centre for Disease Prevention and Control (ECDC) (Service contract No. 11236 and Framework Contract ECDC/2021/016).
dc.identifier.citationBMC Med. 2025 Nov 3;23(1):602. doi: 10.1186/s12916-025-04426-y
dc.identifier.doi10.1186/s12916-025-04426-y
dc.identifier.eissn1741-7015
dc.identifier.pmid41185010
dc.identifier.urihttp://hdl.handle.net/10400.18/10688
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Nature
dc.relationI-MOVE+ Integrated Monitoring of Vaccines Effects in Europe: a platform to measure and compare effectiveness and impact of influenza and pneumococcal vaccines and vaccination strategies in the elderly
dc.relationMultidisciplinary European network for research, prevention and control of the COVID-19 Pandemic
dc.relation.hasversionhttps://link.springer.com/article/10.1186/s12916-025-04426-y
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectInfluenza
dc.subjectVaccine effectiveness
dc.subjectChronic Conditions
dc.subjectEurope
dc.subjectHospital
dc.subjectI-MOVE
dc.subjectVEBIS
dc.subjectInfecções Respiratórias
dc.subjectEstados de Saúde e da Doença
dc.subjectCuidados de Saúde
dc.subjectinfluenza A
dc.titleVaccine effectiveness against influenza A in older adults and the effect of chronic conditions: results from the I-MOVE and VEBIS multicentre European hospital case-control studies, 2015/16-2023/24eng
dc.typejournal article
dcterms.referenceshttps://static-content.springer.com/esm/art%3A10.1186%2Fs12916-025-04426-y/MediaObjects/12916_2025_4426_MOESM1_ESM.docx
dspace.entity.typePublication
oaire.awardTitleI-MOVE+ Integrated Monitoring of Vaccines Effects in Europe: a platform to measure and compare effectiveness and impact of influenza and pneumococcal vaccines and vaccination strategies in the elderly
oaire.awardTitleMultidisciplinary European network for research, prevention and control of the COVID-19 Pandemic
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/634446/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/101003673/EU
oaire.citation.issue1
oaire.citation.startPage602
oaire.citation.titleBMC Medicine
oaire.citation.volume23
oaire.fundingStreamH2020
oaire.fundingStreamH2020
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
relation.isProjectOfPublicationccfd73a6-6f3c-4702-956c-544973bca97d
relation.isProjectOfPublication7403e02d-5360-418c-8e37-687c3a1349f8
relation.isProjectOfPublication.latestForDiscoveryccfd73a6-6f3c-4702-956c-544973bca97d

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