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Signal Transduction Pathways Regulating the Alternative Splicing of Tumor-Related RAC1b

2019-10-19Conference object Restricted access
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dc.contributor.authorGonçalves, Vânia
dc.contributor.authorMatos, Paulo Matos
dc.contributor.authorPereira, Joana
dc.contributor.authorHenriques, Andreia
dc.contributor.authorJordan, Peter
dc.date.accessioned2020-05-27T11:46:43Z
dc.date.available2020-05-27T11:46:43Z
dc.date.issued2019-10-19
dc.description.abstractIntroduction: In colon cancer distinct genetic subtypes have been described, one of which involves overexpression of RAC1b, a variant generated by alternative splicing. Aberrant splicing is known to occur in cancer and can be caused by mutation in a gene or splicing factor but also represents a dynamic response to oncogene-induced cellular signaling and in this case it may be pharmacologically targeted. Here we explore how signaling pathways are involved in the deregulation of alternative RAC1b splicing in colorectal tumor cells.pt_PT
dc.description.sponsorshipThis work was supported by the Fundação para a Ciência e Tecnologia, Portugal and Association Maratona da Saúde.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/6842
dc.language.isoengpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectSignalling Pathwayspt_PT
dc.subjectAlternative Splicingpt_PT
dc.subjectRAC1bpt_PT
dc.subjectSplicing Alternativopt_PT
dc.subjectVias de Transdução de Sinal e Patologias Associadaspt_PT
dc.subjectCancro Coloretalpt_PT
dc.titleSignal Transduction Pathways Regulating the Alternative Splicing of Tumor-Related RAC1bpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceOlhão, Portugalpt_PT
oaire.citation.title10th Meeting on Signal Transduction SINAL 2019, 18-19 outubro 2019pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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