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Cytotoxic effects of single and binary mixtures of metal oxide nanoparticles and metal(loid) on A549 human cell line.

2020-11-19Conference object Restricted access
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dc.contributor.authorRosário, Fernanda
dc.contributor.authorBessa, Maria João
dc.contributor.authorBrandão, Fátima
dc.contributor.authorCosta, Carla
dc.contributor.authorLopes, Cláudia B.
dc.contributor.authorEstrada, Ana Cristina
dc.contributor.authorTavares, Daniela S.
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorReis, Ana Teresa
dc.date.accessioned2021-03-13T18:45:03Z
dc.date.available2021-03-13T18:45:03Z
dc.date.issued2020-11-19
dc.description.abstractBackground, Motivation and Objective: The need to assess the toxicity resulting from exposure to mixtures of chemicals has been recognized by the WHO and EU, as humans are simultaneously exposed to an array of natural and anthropogenic contaminants. Of particular interest are the potential combined effects resulting from interaction of nanoparticles (NPs) and metals. While the first are the current driving force for emerging contaminants, the latter, as legacy contaminants, remain a concern. Metals show strong affinity to NPs, which can change the uptake and toxicity to the organism of each individual contaminant. Studying the effects on the respiratory tract is of upmost relevance because of its constant contact with xenobiotics, resulting in adverse effects on the lung. Considering the above, the objective of this work was to assess and compare viability, cell cycle, and uptake of A549 cells after exposure to single and binary mixtures of titanium dioxide nanoparticles (TiO2NP), cerium oxide nanoparticles (CeO2NP), arsenic (As) and mercury (Hg). These chemicals were chosen because: 1) TiO2NP are among the most abundantly used NPs; 2) CeO2NP have been used in nanomedicine for its high biocompatibility and cytoprotective effect; and 3) As and Hg due to their non‐biodegradable, persistent, and extremely toxic character. This work intends to support adequate human risk assessment resulting from co-exposure to multiple contaminants.pt_PT
dc.description.sponsorshipNanoLegaTox (PTDC/SAU-PUB/29651/2017) cofinanced by COMPETE2020, Portugal2020 and European Union, through FEDER. A.T.Reis, F.Brandão and M.J.Bessa financed by FCT Grants SFRH/BPD/122112/2016, SFRH/BD/101060/2014 and SFRH/BD/12046/2016. A.C.Estrada and C.B.Lopes funded by national funds (OE), in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of article 23, Decree-Law 57/2016, August 29, changed by Law 57/2017, July 19.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7483
dc.language.isoengpt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectMetal Oxide Nanoparticlespt_PT
dc.subjectNanoparticlespt_PT
dc.subjectMetal(loid)pt_PT
dc.subjectA549 Human Cell Linept_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleCytotoxic effects of single and binary mixtures of metal oxide nanoparticles and metal(loid) on A549 human cell line.pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FSAU-PUB%2F29651%2F2017/PT
oaire.citation.conferencePlaceGrenoble, Francept_PT
oaire.citation.title7th International Conference NANOSAFE 2020, 16-20 November 2020pt_PT
oaire.fundingStream9471 - RIDTI
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublication9f23e866-c585-4ebc-af90-ee03cf2d2655
relation.isProjectOfPublication.latestForDiscovery9f23e866-c585-4ebc-af90-ee03cf2d2655

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