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Cytotoxic effects of single and binary mixtures of metal oxide nanoparticles and metal(loid) on A549 human cell line.
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Resumo(s)
Background, Motivation and Objective: The need to assess the toxicity resulting from exposure to mixtures of chemicals has been recognized
by the WHO and EU, as humans are simultaneously exposed to an array of natural and anthropogenic
contaminants. Of particular interest are the potential combined effects resulting from interaction of
nanoparticles (NPs) and metals. While the first are the current driving force for emerging
contaminants, the latter, as legacy contaminants, remain a concern. Metals show strong affinity to
NPs, which can change the uptake and toxicity to the organism of each individual contaminant.
Studying the effects on the respiratory tract is of upmost relevance because of its constant contact with
xenobiotics, resulting in adverse effects on the lung. Considering the above, the objective of this work
was to assess and compare viability, cell cycle, and uptake of A549 cells after exposure to single and
binary mixtures of titanium dioxide nanoparticles (TiO2NP), cerium oxide nanoparticles (CeO2NP),
arsenic (As) and mercury (Hg). These chemicals were chosen because: 1) TiO2NP are among the most
abundantly used NPs; 2) CeO2NP have been used in nanomedicine for its high biocompatibility and
cytoprotective effect; and 3) As and Hg due to their non‐biodegradable, persistent, and extremely toxic
character. This work intends to support adequate human risk assessment resulting from co-exposure
to multiple contaminants.
Descrição
Palavras-chave
Cytotoxicity Metal Oxide Nanoparticles Nanoparticles Metal(loid) A549 Human Cell Line Genotoxicidade Ambiental