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Brain expression of inflammatory mediators in Mesial Temporal Lobe Epilepsy patients

2017-12-15Journal article Restricted access
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dc.contributor.authorLeal, Bárbara
dc.contributor.authorChaves, João
dc.contributor.authorCarvalho, Cláudia
dc.contributor.authorRangel, Rui
dc.contributor.authorSantos, Agostinho
dc.contributor.authorBettencourt, Andreia
dc.contributor.authorLopes, João
dc.contributor.authorRamalheira, João
dc.contributor.authorSilva, Berta M.
dc.contributor.authorda Silva, António Martins
dc.contributor.authorCosta, Paulo P.
dc.date.accessioned2018-03-22T15:43:51Z
dc.date.available2021-12-16T01:30:11Z
dc.date.issued2017-12-15
dc.description.abstractNeuroinflammation may be central in epileptogenesis. In this study we analysed inflammatory reaction markers in brain tissue of Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) patients. TLR4, IL-1β and IL-10 gene expression as well as the presence of activated HLA-DR+ microglia was evaluated in 23 patients and 10 cadaveric controls. Inflammation characterized by the presence of HLA-DR+microglia and TLR4, IL-1β overexpression was evident in hippocampus and anterior temporal cortex of MTLE-HS patients. Anti-inflammatory IL-10 was also overexpressed in MTLE-HS patients. Our results show that hippocampal neuroinflammation extends beyond lesional limits, as far as the anterior temporal cortex.pt_PT
dc.description.sponsorshipThis research was partial supported by a FCT grant PIC/IC/83297/2007.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Neuroimmunol. 2017 Dec 15;313:82-88. doi: 10.1016/j.jneuroim.2017.10.014. Epub 2017 Nov 6pt_PT
dc.identifier.doi10.1016/j.jneuroim.2017.10.014pt_PT
dc.identifier.issn0165-5728
dc.identifier.urihttp://hdl.handle.net/10400.18/5430
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/International Society for Neuroimmunologypt_PT
dc.relationThe relevance of HHV-6B in patients with Mesial Temporal Lobe Epilepsy (MTLE) due to Hippocampal Sclerosis (HS): implications in prevention and treatment
dc.relation.publisherversionhttp://www.jni-journal.com/article/S0165-5728(17)30194-7/fulltextpt_PT
dc.subjectAdultpt_PT
dc.subjectBrainpt_PT
dc.subjectCytokinespt_PT
dc.subjectEpilepsy, Temporal Lobept_PT
dc.subjectFemalept_PT
dc.subjectHLA-DR Antigenspt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMicrogliapt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectToll-Like Receptor 4pt_PT
dc.subjectYoung Adultpt_PT
dc.subjectDoenças Genéticaspt_PT
dc.titleBrain expression of inflammatory mediators in Mesial Temporal Lobe Epilepsy patientspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleThe relevance of HHV-6B in patients with Mesial Temporal Lobe Epilepsy (MTLE) due to Hippocampal Sclerosis (HS): implications in prevention and treatment
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PIC%2FIC%2F83297%2F2007/PT
oaire.citation.endPage88pt_PT
oaire.citation.startPage82pt_PT
oaire.citation.titleJournal of Neuroimmunologypt_PT
oaire.citation.volume313pt_PT
oaire.fundingStream5876-PPCDTI
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationb26c14e9-3945-4701-b308-16a4f93c49f3
relation.isProjectOfPublication.latestForDiscoveryb26c14e9-3945-4701-b308-16a4f93c49f3

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