Brain expression of inflammatory mediators in Mesial Temporal Lobe Epilepsy patients

Neuroinflammation may be central in epileptogenesis. In this study we analysed inflammatory reaction markers in brain tissue of Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) patients. TLR4, IL-1β and IL-10 gene expression as well as the presence of activated HLA-DR+ microglia was evaluated in 23 patients and 10 cadaveric controls. Inflammation characterized by the presence of HLA-DR+microglia and TLR4, IL-1β overexpression was evident in hippocampus and anterior temporal cortex of MTLE-HS patients. Anti-inflammatory IL-10 was also overexpressed in MTLE-HS patients. Our results show that hippocampal neuroinflammation extends beyond lesional limits, as far as the anterior temporal cortex.

Palavras-chave

Adult Brain Cytokines Epilepsy, Temporal Lobe Female HLA-DR Antigens Humans Male Microglia Middle Aged Toll-Like Receptor 4 Young Adult Doenças Genéticas

URI

http://hdl.handle.net/10400.18/5430

Citação

J Neuroimmunol. 2017 Dec 15;313:82-88. doi: 10.1016/j.jneuroim.2017.10.014. Epub 2017 Nov 6

Projetos de investigação

The relevance of HHV-6B in patients with Mesial Temporal Lobe Epilepsy (MTLE) due to Hippocampal Sclerosis (HS): implications in prevention and treatment

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Editora

Elsevier/International Society for Neuroimmunology

DOI

10.1016/j.jneuroim.2017.10.014

Coleções

DGH - Artigos em revistas internacionais

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