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Genotoxicity study of human astrocytes exposed to oleic acid-coated iron oxide nanoparticles

2020-08Conference object Restricted access
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dc.contributor.authorValdiglesias, Vanessa
dc.contributor.authorFernández-Bertólez, Natalia
dc.contributor.authorCosta, Carla
dc.contributor.authorBrandão, Fátima
dc.contributor.authorTeixeira, Joao Paulo
dc.contributor.authorPásaro, Eduardo
dc.contributor.authorLaffon, Blanca
dc.date.accessioned2021-03-13T19:08:48Z
dc.date.available2021-03-13T19:08:48Z
dc.date.issued2020-08
dc.description.abstractIron oxide nanoparticles (ION) have attracted much attention in last decade for their utility in several biomedical applications such as magnetic resonance imaging, hyperthermia-based cancer therapy, and targeted drug/gene delivery. Particularly, previous works showed that ION can cross the blood-brain barrier, making them especially useful as diagnostic and therapeutic tools, specifically in central nervous system diseases (reviewed in Kiliç et al., 2017). Although oleic acid-coated ION (O-ION) show in general good stability and biocompatibility, toxicological studies about their effect in human nervous cells are scant so far. Neurotoxicity assessment is therefore crucial to establish safety conditions for O-ION biomedical uses. Hence, the main objective of this work was to assess the potential genotoxic damage induced on human glial cells (A172 astrocytes) by exposure to O-ION.pt_PT
dc.description.sponsorshipXunta de Galicia (ED431B 2019/02), Ministerio de Educación, Cultura y Deporte (BEAGAL18/00142 to V.), Deputación Provincial de A Coruña (to N.F.-B.), and FCT (subsidized by national fund of MCTES, SFRH/BD/101060/2014 [to F.B.]). Authors would also like to acknowledge COST Action CA15132 “The comet assay as a human biomonitoring tool (hCOMET)”.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7488
dc.language.isoengpt_PT
dc.subjectGenotoxicitypt_PT
dc.subjectHuman Astrocytes Exposedpt_PT
dc.subjectIron Oxide Nanoparticlespt_PT
dc.subjectNanoparticlespt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleGenotoxicity study of human astrocytes exposed to oleic acid-coated iron oxide nanoparticlespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLund, Sweden (online)pt_PT
oaire.citation.titleInternational Nanoscience Student Conference (INASCON 2020), 11-13 August 2020pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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