Genotoxicity study of human astrocytes exposed to oleic acid-coated iron oxide nanoparticles

Valdiglesias, Vanessa; Fernández-Bertólez, Natalia; Costa, Carla; Brandão, Fátima; Teixeira, Joao Paulo; Pásaro, Eduardo; Laffon, Blanca

http://hdl.handle.net/10400.18/7488

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Authors

Valdiglesias, Vanessa

Fernández-Bertólez, Natalia

Abstract(s)

Iron oxide nanoparticles (ION) have attracted much attention in last decade for their utility in several biomedical applications such as magnetic resonance imaging, hyperthermia-based cancer therapy, and targeted drug/gene delivery. Particularly, previous works showed that ION can cross the blood-brain barrier, making them especially useful as diagnostic and therapeutic tools, specifically in central nervous system diseases (reviewed in Kiliç et al., 2017). Although oleic acid-coated ION (O-ION) show in general good stability and biocompatibility, toxicological studies about their effect in human nervous cells are scant so far. Neurotoxicity assessment is therefore crucial to establish safety conditions for O-ION biomedical uses. Hence, the main objective of this work was to assess the potential genotoxic damage induced on human glial cells (A172 astrocytes) by exposure to O-ION.