Publicação
Mouse model of Schistosomiasis: infection with Schistosoma mansoni in CD-1 mice
| dc.contributor.author | Luis, C. | |
| dc.contributor.author | Soares, R. | |
| dc.contributor.author | Fernandes, R. | |
| dc.contributor.author | Botelho, M. | |
| dc.date.accessioned | 2020-05-23T14:19:28Z | |
| dc.date.available | 2020-05-23T14:19:28Z | |
| dc.date.issued | 2019-01 | |
| dc.description.abstract | Schistosomiasis is a parasitic disease that affects almost 240 million worldwide. CD1 mice were infected with cercariae of S. mansoni, after which infection developed for 8 weeks. Tissues were processed to immuno-histological techniques. It was performed H&E staining for overall analyses, Sirius Red for fibrosis and immunohistochemistry for inflammation biomarkers. The most infected organ was the liver, fibrosis decreased with egg development and Galectin-3 (Gal3) and Interleukin 6 (IL-6) were expressed inside granulomas | pt_PT |
| dc.description.sponsorship | This work was also supported by FCT – Fundação para a Ciência e Tecnologia (REF UID/BIM/04293/2013) and by the project NORTE-01-0145-FEDER-000012 and by a scholarship to Carla Luís with the reference SAICT2016/FEDER/BIO4DIA/BTI under the supervision of Dr. Rúben Fernandes. | pt_PT |
| dc.description.version | N/A | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/6776 | |
| dc.language.iso | eng | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt_PT |
| dc.subject | Schistosomiasis | pt_PT |
| dc.subject | Schistosoma mansoni | pt_PT |
| dc.subject | Infecções Sistémicas e Zoonoses | pt_PT |
| dc.title | Mouse model of Schistosomiasis: infection with Schistosoma mansoni in CD-1 mice | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04293%2F2013/PT | |
| oaire.citation.conferencePlace | LabRoots | pt_PT |
| oaire.citation.title | Laboratory Animal Sciences Virtual Event, 31 January 2019 | pt_PT |
| oaire.fundingStream | 5876 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
| relation.isProjectOfPublication | fa9009ed-65e1-4108-bd20-1304211124ea | |
| relation.isProjectOfPublication.latestForDiscovery | fa9009ed-65e1-4108-bd20-1304211124ea |
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