Mouse model of Schistosomiasis: infection with Schistosoma mansoni in CD-1 mice

Luis, C.; Soares, R.; Fernandes, R.; Botelho, M.

http://hdl.handle.net/10400.18/6776

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Mouse model of Schistosomiasis infection with Schistosoma mansoni in CD1 mice.pdf		1.27 MB	Adobe PDF	Ver/Abrir

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Schistosomiasis is a parasitic disease that affects almost 240 million worldwide. CD1 mice were infected with cercariae of S. mansoni, after which infection developed for 8 weeks. Tissues were processed to immuno-histological techniques. It was performed H&E staining for overall analyses, Sirius Red for fibrosis and immunohistochemistry for inflammation biomarkers. The most infected organ was the liver, fibrosis decreased with egg development and Galectin-3 (Gal3) and Interleukin 6 (IL-6) were expressed inside granulomas