Publication
Signal Transduction Pathways Regulating Alternative Splicing of RAC1b
| dc.contributor.author | Gonçalves, Vânia | |
| dc.contributor.author | Matos, Paulo | |
| dc.contributor.author | Henriques, Andreia | |
| dc.contributor.author | Pereira, Joana | |
| dc.contributor.author | Jordan, Peter | |
| dc.date.accessioned | 2018-03-06T17:39:21Z | |
| dc.date.available | 2018-03-06T17:39:21Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | In colon cancer distinct genetic subtypes have been described, one of which involves overexpression of RAC1b, a variant generated by alternative splicing. Aberrant splicing is known to occur in cancer and can be caused by mutation in a gene or splicing factor but also represents a dynamic response to oncogene-induced cellular signaling and in this case it may be pharmacologically targeted. Here we explore how signaling pathways are involved in the deregulation of alternative RAC1b splicing in tumor cells. | pt_PT |
| dc.description.sponsorship | This work was supported by the Fundação para a Ciência e Tecnologia, Portugal and Association Maratona da Saúde. | pt_PT |
| dc.description.version | info:eu-repo/semantics/draft | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/5234 | |
| dc.language.iso | eng | pt_PT |
| dc.subject | RAC1b | pt_PT |
| dc.subject | Colon Cancer | pt_PT |
| dc.subject | Splicing Alternativo | pt_PT |
| dc.subject | Vias de Transdução de Sinal e Patologias Associadas | pt_PT |
| dc.subject | Cancro Coloretal | pt_PT |
| dc.title | Signal Transduction Pathways Regulating Alternative Splicing of RAC1b | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.title | SINAL 2017- 8th international meeting on signal transduction, 1-2 junho 2017, Lisboa, Portugal | pt_PT |
| oaire.citation.title | ESMO 2017- European Society of Medical Oncology annual meeting, 8-12 September 2017, Madrid, Spain | |
| rcaap.rights | closedAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |