Signal Transduction Pathways Regulating Alternative Splicing of RAC1b

Gonçalves, Vânia; Matos, Paulo; Henriques, Andreia; Pereira, Joana; Jordan, Peter

http://hdl.handle.net/10400.18/5234

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Abstract(s)

In colon cancer distinct genetic subtypes have been described, one of which involves overexpression of RAC1b, a variant generated by alternative splicing. Aberrant splicing is known to occur in cancer and can be caused by mutation in a gene or splicing factor but also represents a dynamic response to oncogene-induced cellular signaling and in this case it may be pharmacologically targeted. Here we explore how signaling pathways are involved in the deregulation of alternative RAC1b splicing in tumor cells.