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Low and decreasing vaccine effectiveness against influenza A(H3) in 2011/12 among vaccination target groups in Europe: results from the I-MOVE multicentre case-control study

2013-01-31Journal article Open access
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dc.contributor.authorKissling, E.
dc.contributor.authorValenciano, M.
dc.contributor.authorLarrauri, A.
dc.contributor.authorOroszi, B.
dc.contributor.authorCohen, J.M.
dc.contributor.authorNunes, Baltazar
dc.contributor.authorPitigoi, D.
dc.contributor.authorRizzo, C.
dc.contributor.authorRebolledo, J.
dc.contributor.authorParadowska-Stankiewicz, I.
dc.contributor.authorJiménez-Jorge, S.
dc.contributor.authorHorváth, J.K.
dc.contributor.authorDaviaud, I.
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorNecula, G.
dc.contributor.authorBella, A.
dc.contributor.authorO'Donnell, J.
dc.contributor.authorGłuchowska, M.
dc.contributor.authorCiancio, B.C.
dc.contributor.authorNicoll, A.
dc.contributor.authorMoren, A.
dc.date.accessioned2014-01-31T12:31:51Z
dc.date.available2014-01-31T12:31:51Z
dc.date.issued2013-01-31
dc.description.abstractWithin the Influenza Monitoring Vaccine Effectiveness in Europe (I-MOVE) project we conducted a multicentre case–control study in eight European Union (EU) Member States to estimate the 2011/12 influenza vaccine effectiveness against medically attended influenza-like illness (ILI) laboratory-confirmed as influenza A(H3) among the vaccination target groups. Practitioners systematically selected ILI / acute respiratory infection patients to swab within seven days of symptom onset. We restricted the study population to those meeting the EU ILI case definition and compared influenza A(H3) positive to influenza laboratory-negative patients. We used logistic regression with study site as fixed effect and calculated adjusted influenza vaccine effectiveness (IVE), controlling for potential confounders (age group, sex, month of symptom onset, chronic diseases and related hospitalisations, number of practitioner visits in the previous year). Adjusted IVE was 25% (95% confidence intervals (CI): -6 to 47) among all ages (n=1,014), 63% (95% CI: 26 to 82) in adults aged between 15 and 59 years and 15% (95% CI: -33 to 46) among those aged 60 years and above. Adjusted IVE was 38% (95%CI: -8 to 65) in the early influenza season (up to week 6 of 2012) and -1% (95% CI: -60 to 37) in the late phase. The results suggested a low adjusted IVE in 2011/12. The lower IVE in the late season could be due to virus changes through the season or waning immunity. Virological surveillance should be enhanced to quantify change over time and understand its relation with duration of immunological protection. Seasonal influenza vaccines should be improved to achieve acceptable levels of protection.por
dc.description.sponsorshipECDCpor
dc.identifier.citationEuro Surveill. 2013 Jan 31;18(5). pii: 20390por
dc.identifier.issn1560-7917
dc.identifier.urihttp://hdl.handle.net/10400.18/1889
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherECDC-European Centre for Disease Prevention and Controlpor
dc.relationIMOVE e EUROREVApor
dc.relation.publisherversionhttp://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20390por
dc.subjectEstados de Saúde e de Doençapor
dc.subjectGripepor
dc.subjectVacinapor
dc.subjectCoberturapor
dc.subjectInfluenza A(H3)por
dc.subjectVaccinepor
dc.subjectEuropean Unionpor
dc.subjectI- MOVEpor
dc.subjectÉpoca 2011/2012por
dc.titleLow and decreasing vaccine effectiveness against influenza A(H3) in 2011/12 among vaccination target groups in Europe: results from the I-MOVE multicentre case-control studypor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPagepii: 20390por
oaire.citation.titleEurosurveillancepor
oaire.citation.volume18(5)por
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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