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Exposure of Portuguese population to mycoestrogens: a public health concern?

2019-05Conference object Restricted access
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dc.contributor.authorMartins, Carla
dc.contributor.authorVidal, Arnau
dc.contributor.authorDe Saeger, Sarah
dc.contributor.authorNunes, Carla
dc.contributor.authorTorres, D.
dc.contributor.authorGoios, A.
dc.contributor.authorLopes, C.
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorAlvito, Paula
dc.contributor.authorDe Boevre, M.
dc.date.accessioned2020-05-15T11:04:13Z
dc.date.available2020-05-15T11:04:13Z
dc.date.issued2019-05
dc.description.abstractAlternariol (AOH) and zearalenone (ZEN) are mycotoxins that occur widely in food commodities, with particular incidence in cereals [1,2]. Both mycotoxins present estrogenic effects, therefore, it is crucial to assess the human exposure and the associated risk [2,3]. To date, there is a lack of human studies to assess exposure to ZEN and AOH through biomarkers analysis in Portugal. In the scope of the National Food, Nutrition, and Physical Activity Survey of the Portuguese General Population (IAN-AF, 2015-2016), 94 participants collected 24h-urine samples [4]. Following a salt-assisted matrix extraction, urine samples were analyzed by liquid chromatography–mass spectrometry (LC-MS/MS) for the simultaneous determination of ZEN, α-zearalenol (α-ZEL), β -zearalenol (β-ZEL), α-zearalanol (α-ZAL), β-zearalanol (β-ZAL), zearalanone (ZAN), zearalenone-14-glucoside (ZEN-14-GlcA), α-zearalenol-glucoside (α-ZEL-GlcA), β-zearalenolglucoside (β-ZEL-GlcA), zearalenone-14-sulfate (ZEN-14-Sulf), alternariol monomethyl ether (AME) and AOH. Risk characterization was performed using the Hazard Quotient (HQ) approach. ZEN, ZEN-14-GlcA and AOH were detected in 48%, 16% and 29% of analyzed samples, respectively, and median levels were 0.17 μg/L for ZEN and ZEN-14-GlcA and 0.28 μg/L for AOH. Participants were exposed to ZEN (n=35), AOH (n=15) and some volunteers showed co-exposure to both mycotoxins (n=12). Risk characterization of exposure to ZEN was performed and 24% of participants presented a HQ > 1, thus exceeding the Tolerable Daily Intake (TDI) of 0.250 μg/kg bw/day. There is no toxicological data available to support the establishment of a TDI for AOH, thus the risk associated with this toxin was not characterized [2,5]. The present study generated, for the first time and within a human biomonitoring study, reliable data regarding the exposure of the Portuguese population to ZEN and AOH. These data are crucial to perform a more realistic risk assessment, contributing to more effective preventive measures for health protection of the Portuguese population.pt_PT
dc.description.sponsorshipThanks are due for the financial support to CESAM (UID/AMB/50017/2019), to FCT/MEC through national funds, and the co-funding by the FEDER, within the PT2020 Partnership Agreement and Compete 2020. The authors also acknowledge the support of MYTOX-SOUTH project.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/6664
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAlternariolpt_PT
dc.subjectZearalenonept_PT
dc.subjectMycotoxinspt_PT
dc.subjectPortugalpt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectToxicologiapt_PT
dc.subjectAvaliação de Riscopt_PT
dc.subjectSaúde Humanapt_PT
dc.titleExposure of Portuguese population to mycoestrogens: a public health concern?pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.title41st Mycotoxin Workshop, Lisbon School of Health Technology (Instituto Politécnico de Lisboa)/ Society for Mycotoxin Research, 6-8 May 2019pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublication1d7db62a-6440-4ccb-a5cc-c3f76c8585b3
relation.isProjectOfPublication.latestForDiscovery1d7db62a-6440-4ccb-a5cc-c3f76c8585b3

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