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A scoping review of the health effects of fermented foods in specific human populations and their potential role in precision nutrition: current knowledge and gaps

2025-11-13Journal article Open access
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosCiências Agrárias::Outras Ciências Agrárias
datacite.subject.sdg02:Erradicar a Fome
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorHumblot, Christèle
dc.contributor.authorAlvanoudi, Panagiota
dc.contributor.authorAlves, Emilia
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorBelovic, Miona
dc.contributor.authorBulmus-Tuccar, Tugce
dc.contributor.authorChassard, Christophe
dc.contributor.authorDerrien, Muriel
dc.contributor.authorFevzi Karagöz, Mustafa
dc.contributor.authorKarakaya, Sibel
dc.contributor.authorLaranjo, Marta
dc.contributor.authorTh Mantzouridou, Fani
dc.contributor.authorRosado, Catarina
dc.contributor.authorPracer, Smilja
dc.contributor.authorSaar, Helen
dc.contributor.authorTap, Julien
dc.contributor.authorTreven, Primož
dc.contributor.authorVergères, Guy
dc.contributor.authorPertziger, Eugenia
dc.contributor.authorSavary-Auzeloux, Isabelle
dc.date.accessioned2026-01-16T16:48:29Z
dc.date.available2026-01-16T16:48:29Z
dc.date.issued2025-11-13
dc.description.abstractBackground: Diets and specific foods have a significant impact on health, and individual responses to nutritional factors vary. This variability among humans can be considered a basis for developing personalized or precision nutrition. Fermented foods (FF) contain a wide range of macro- and micronutrients, bioactive compounds, and live or dead microorganisms. FF represent a diverse range of products and have garnered significant interest due to their potential health benefits. However, consistent evidence remains limited, possibly due to heterogeneity in individual responses. Objectives: The objective of this review is to assess and compile existing evidence on the variable responses of populations to FF and to determine whether FF could be integrated into a precision nutrition strategy. Design: Interventional and observational human studies were systematically collected. The publication identified the main factors likely to contribute to variable responses to FF across all health outcomes. The question was systematically addressed to assess the available evidence and identify knowledge gaps, guiding future research. A pragmatic approach was employed, following EFSA health claim guidelines, which require an assessment of food characteristics and mechanisms of action, as well as conducting a systematic search of human interventional studies. A similar approach was used to analyze data extracted from observational studies. The population included all humans (healthy and non-healthy, of all ages), encompassing both observational and interventional studies. The intervention consisted of the ingestion of any FF, while the control was defined as the absence or lower consumption of FF or consumption of a corresponding non-FF. Outcomes included all markers of the population's health status. Results: The main factors contributing to variable responses to FF across all health outcomes were related to initial phenotypic characteristics (biological sex, geographical origin, hormonal status, and age), baseline health status [metabolic syndrome [MetS], chronic metabolic pathologies, cancer, and psychological disorders], and genetic background. Additionally, since the gut microbiota is person-specific and influences metabolic responses, particular attention was paid to its functions and role in the variability of population responses to FF. Conclusion: Collectively, this review represents a first step toward evaluating the feasibility of using FF in tailored nutritional strategies.eng
dc.description.sponsorshipThis article/publication is based upon work from COST Action PIMENTO CA20128, supported by COST (European Cooperation in Science and Technology). The authors thank Alisa Berger (University Library Medicine, University of Zürich, Zürich, Switzerland) for support on the development of the PIMENTO Literature Search String (PIMENTO-LS). The authors also thank the administrative team of PIMENTO for their support, particularly Nadège Picard and Elena Gerbaud (INRAE). The authors thank MED (https://doi.org/10.54499/UIDB/05183/2020; https://doi.org/10.54499/UIDP/05183/2020) and CHANGE (https://doi.org/10.54499/LA/P/0121/2020).
dc.identifier.citationFront Nutr. 2025 Nov 13:12:1650633. doi: 10.3389/fnut.2025.1650633. eCollection 2025
dc.identifier.doi10.3389/fnut.2025.1650633
dc.identifier.issn2296-861X
dc.identifier.pmid41377570
dc.identifier.urihttp://hdl.handle.net/10400.18/10709
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media
dc.relationUIDB/05183/2020
dc.relationUIDP/05183/2020
dc.relationLA/P/0121/2020
dc.relation.hasversionhttps://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1650633/full
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCoffee
dc.subjectFermented Food
dc.subjectGut Microbiota
dc.subjectMetabolic Syndrome
dc.subjectPersonalized Nutrition
dc.subjectPopulation Variability
dc.subjectYogurt
dc.subjectNutrição Aplicada
dc.subjectEstilos de Vida e Impacto na Saúde
dc.titleA scoping review of the health effects of fermented foods in specific human populations and their potential role in precision nutrition: current knowledge and gapseng
dc.typejournal article
dcterms.referenceshttps://www.frontiersin.org/api/v4/articles/1650633/file/Table_1.docx/1650633_table_1/1
dspace.entity.typePublication
oaire.citation.startPage1650633
oaire.citation.titleFrontiers in Nutrition
oaire.citation.volume12
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameAssunção
person.givenNameRicardo
person.identifier481718
person.identifier.ciencia-id5B1D-9EB4-E1D4
person.identifier.orcid0000-0002-4375-0456
person.identifier.ridE-2738-2014
person.identifier.scopus-author-id56330129500
relation.isAuthorOfPublicatione69f935e-bb21-495a-b274-35d2e945648c
relation.isAuthorOfPublication.latestForDiscoverye69f935e-bb21-495a-b274-35d2e945648c

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