Publication
Uncovering the role of positive selection in the evolutionary pathways to influenza virus resistance or reduced inhibition by neuraminidase inhibitors
| dc.contributor.author | Correia, Vanessa | |
| dc.contributor.author | Abecasis, Ana | |
| dc.contributor.author | Rebelo de Andrade, Helena | |
| dc.date.accessioned | 2017-03-14T14:35:57Z | |
| dc.date.available | 2017-03-14T14:35:57Z | |
| dc.date.issued | 2016-08 | |
| dc.description.abstract | This study aimed at estimating the site-specific SP on the NA gene of currently circulating human influenza viruses, in order to infer the SP acting specifically on the sites associated with (H)RI by NAIs and on further sites contacting directly or indirectly with the drug (active site). The frequency of drug-resistant and (H)RI variants was determined as a secondary objective, prompted by the need of determining the entire amino acid composition of the sites to understand SP data | pt_PT |
| dc.description.sponsorship | Portuguese Science and Technology Foundation (FCT) for financial support (doctoral grant SFRH/BD/48532/2008). Faculty of Pharmacy, Universidade de Lisboa, for general support. | |
| dc.description.version | N/A | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/4638 | |
| dc.language.iso | eng | pt_PT |
| dc.subject | Neuraminidase Inhibitors | pt_PT |
| dc.subject | influenza Antivirals | pt_PT |
| dc.subject | Influenza Viruses | pt_PT |
| dc.subject | Drug Resistance | pt_PT |
| dc.subject | Virus Neuraminidase | pt_PT |
| dc.subject | Antibody Selective Pressure | pt_PT |
| dc.subject | Resistência aos Antimicrobianos | pt_PT |
| dc.title | Uncovering the role of positive selection in the evolutionary pathways to influenza virus resistance or reduced inhibition by neuraminidase inhibitors | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Chicago, USA | pt_PT |
| oaire.citation.title | Options IX for The Control of Influenza, 24-28 Aug 2016 | pt_PT |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |