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Uncovering the role of positive selection in the evolutionary pathways to influenza virus resistance or reduced inhibition by neuraminidase inhibitors
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| 1.14 MB | Adobe PDF |
Orientador(es)
Resumo(s)
This study aimed at estimating the site-specific SP on the
NA gene of currently circulating human influenza viruses, in
order to infer the SP acting specifically on the sites
associated with (H)RI by NAIs and on further sites
contacting directly or indirectly with the drug (active site).
The frequency of drug-resistant and (H)RI variants was
determined as a secondary objective, prompted by the
need of determining the entire amino acid composition of
the sites to understand SP data
Descrição
Palavras-chave
Neuraminidase Inhibitors influenza Antivirals Influenza Viruses Drug Resistance Virus Neuraminidase Antibody Selective Pressure Resistência aos Antimicrobianos