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Towards a nanospecific approach for risk assessment.

2016-10Journal article Open access
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dc.contributor.authorDekkers, S.
dc.contributor.authorOomen, A.G.
dc.contributor.authorBleeker, E.A.
dc.contributor.authorVandebriel, RJ..
dc.contributor.authorMicheletti, C.
dc.contributor.authorCabellos, J.
dc.contributor.authorJaner, G.
dc.contributor.authorFuentes, N.
dc.contributor.authorVázquez-Campos, S.
dc.contributor.authorBorges, T.
dc.contributor.authorSilva, M.J.
dc.contributor.authorPrina-Mello, A.
dc.contributor.authorMovia, D.
dc.contributor.authorNesslany, F.
dc.contributor.authorRibeiro, A.R.
dc.contributor.authorLeite, P.E.
dc.contributor.authorGroenewold, M.
dc.contributor.authorCassee, F.R.
dc.contributor.authorSips, A.J.
dc.contributor.authorDijkzeul, A.
dc.contributor.authorvan Teunenbroek, T.
dc.contributor.authorWijnhoven, S.W.
dc.date.accessioned2017-03-03T17:52:45Z
dc.date.available2017-03-03T17:52:45Z
dc.date.issued2016-10
dc.description.abstractIn the current paper, a new strategy for risk assessment of nanomaterials is described, which builds upon previous project outcomes and is developed within the FP7 NANoREG project. NANoREG has the aim to develop, for the long term, new testing strategies adapted to a high number of nanomaterials where many factors can affect their environmental and health impact. In the proposed risk assessment strategy, approaches for (Quantitative) Structure Activity Relationships ((Q)SARs), grouping and read-across are integrated and expanded to guide the user how to prioritise those nanomaterial applications that may lead to high risks for human health. Furthermore, those aspects of exposure, kinetics and hazard assessment that are most likely to be influenced by the nanospecific properties of the material under assessment are identified. These aspects are summarised in six elements, which play a key role in the strategy: exposure potential, dissolution, nanomaterial transformation, accumulation, genotoxicity and immunotoxicity. With the current approach it is possible to identify those situations where the use of nanospecific grouping, read-across and (Q)SAR tools is likely to become feasible in the future, and to point towards the generation of the type of data that is needed for scientific justification, which may lead to regulatory acceptance of nanospecific applications of these tools.pt_PT
dc.description.sponsorshipThe research leading to these results has been partially funded by the European Union Seventh Framework Programme (FP7/ 2007e2013) under the project NANoREG (A common European approach to the regulatory testing of nanomaterials), grant agreement 310584.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRegul Toxicol Pharmacol. 2016 Oct;80:46-59. doi: 10.1016/j.yrtph.2016.05.037. Epub 2016 May 30pt_PT
dc.identifier.doi0.1016/j.yrtph.2016.05.037pt_PT
dc.identifier.issn0273-2300
dc.identifier.urihttp://hdl.handle.net/10400.18/4465
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationA common European approach to the regulatory testing of nanomaterials
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0273230016301581pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectNanomaterialspt_PT
dc.subjectRisk Assessment Approachpt_PT
dc.subjectTesting Strategypt_PT
dc.subject(Q)SARspt_PT
dc.subjectGroupingpt_PT
dc.subjectPrioritisationpt_PT
dc.subjectRead-acrosspt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleTowards a nanospecific approach for risk assessment.pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleA common European approach to the regulatory testing of nanomaterials
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/310584/EU
oaire.citation.endPage59pt_PT
oaire.citation.startPage46pt_PT
oaire.citation.titleRegulatory Toxicology and Pharmacologypt_PT
oaire.citation.volume80pt_PT
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationf9fe5c15-606f-4958-ac4b-8109981d34c7
relation.isProjectOfPublication.latestForDiscoveryf9fe5c15-606f-4958-ac4b-8109981d34c7

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