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Therapeutic approaches targeting the serrated pathway of colorectal cancer characterized by mutation in the BRAF gene and overexpression of GTPase RAC1b

2017-06Book part Restricted access
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dc.contributor.authorMatos, Paulo
dc.contributor.authorGonçalves, Vânia
dc.contributor.authorJordan, Peter
dc.date.accessioned2018-02-02T12:19:39Z
dc.date.available2018-02-02T12:19:39Z
dc.date.issued2017-06
dc.description.abstractAround 30% of all colorectal cancer cases are derived from the serrated polyp pathway and mostly carry a mutation in the BRAF gene. Here, we review the current knowledge about the association of this tumor subtype with the CpG island methylator and microsatellite instability phenotypes, immune cell infiltration, and overexpression of GTPase Rac1b. The corresponding therapeutic approaches for targeting these molecular characteristics are presented and critically discussed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMatos P, Goncalves V, Jordan P (2017). Therapeutic approaches targeting the serrated pathway of colorectal cancer characterized by mutation in the BRAF gene and overexpression of GTPase RAC1b, in: Cho CH (ed), Therapeutic targets for Inflammation and Cancer: Novel Therapies for Digestive Diseases, World Scientific, Singapore, pp 233-255 (ISBN: 978-981-3148-56-7 (print), 978-981-3148-58-1 (e-book)pt_PT
dc.identifier.doi10.1142/9789813148574_0011pt_PT
dc.identifier.isbn78-981-3148-56-7 (print)
dc.identifier.issn978-981-3148-58-1 (e-book)
dc.identifier.urihttp://hdl.handle.net/10400.18/4917
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWorld Scientific, Singaporept_PT
dc.relation.publisherversionhttp://www.worldscientific.com/worldscibooks/10.1142/10251pt_PT
dc.subjectColorectal Cancerpt_PT
dc.subjectBRAFpt_PT
dc.subjectRAC1bpt_PT
dc.subjectinflammationpt_PT
dc.subjectVias de Transdução de Sinal e Patologias Associadaspt_PT
dc.subjectCancro coloretalpt_PT
dc.subjectinflamaçãopt_PT
dc.titleTherapeutic approaches targeting the serrated pathway of colorectal cancer characterized by mutation in the BRAF gene and overexpression of GTPase RAC1bpt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.conferencePlaceSingaporept_PT
oaire.citation.endPage255pt_PT
oaire.citation.startPage233pt_PT
oaire.citation.titleTherapeutic targets for Inflammation and Cancer: Novel Therapies for Digestive Diseasespt_PT
rcaap.embargofctVenda comercial pela editora.pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typebookPartpt_PT

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