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Therapeutic approaches targeting the serrated pathway of colorectal cancer characterized by mutation in the BRAF gene and overexpression of GTPase RAC1b
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Orientador(es)
Resumo(s)
Around 30% of all colorectal cancer cases are derived from the serrated polyp
pathway and mostly carry a mutation in the BRAF gene. Here, we review the
current knowledge about the association of this tumor subtype with the CpG
island methylator and microsatellite instability phenotypes, immune cell
infiltration, and overexpression of GTPase Rac1b. The corresponding therapeutic
approaches for targeting these molecular characteristics are presented
and critically discussed.
Descrição
Palavras-chave
Colorectal Cancer BRAF RAC1b inflammation Vias de Transdução de Sinal e Patologias Associadas Cancro coloretal inflamação
Contexto Educativo
Citação
Matos P, Goncalves V, Jordan P (2017). Therapeutic approaches targeting the serrated pathway of colorectal cancer characterized by mutation in the BRAF gene and overexpression of GTPase RAC1b, in: Cho CH (ed), Therapeutic targets for Inflammation and Cancer: Novel Therapies for Digestive Diseases, World Scientific, Singapore, pp 233-255 (ISBN: 978-981-3148-56-7 (print), 978-981-3148-58-1 (e-book)
Editora
World Scientific, Singapore