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Molecular footprints of selective pressure in the neuraminidase gene of currently circulating human influenza subtypes and lineages

2018-09Journal article Restricted access
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dc.contributor.authorCorreia, Vanessa
dc.contributor.authorAbecasis, Ana B.
dc.contributor.authorRebelo-de-Andrade, Helena
dc.date.accessioned2019-03-27T11:25:11Z
dc.date.available2019-03-27T11:25:11Z
dc.date.issued2018-09
dc.description.abstractInfluenza neuraminidase (NA) is under selective pressure (SP) of both host immune system and drug use. Here, we assembled large datasets of NA sequences of worldwide circulating viruses to estimate the global and site-specific SP acting on all current subtypes/lineages of human influenza NA. An overall negative SP of similar magnitude and a prevalence of negatively selected sites were observed for all subtypes/lineages. Positively selected sites varied according to the subtype/lineage, including N1-NA sites 247 and 275, N2-NA sites 148 and 151, and B/Victoria-NA site 395 associated with drug-resistance or reduced susceptibility. These results evidenced a potential role of positive selection in the low-level spread of A(H1N1)pdm09-H275Y drug-resistant viruses, and alerted for a potential higher risk of spread of a synergistic A(H1N1)pdm09 drug-resistant variant (H275Y/S247N). The positive selection detected at N2-NA sites 148 and 151 was probably an artefact from cell-culture. Overall mapping revealed six potential new druggable regions.pt_PT
dc.description.sponsorshipV. Correia was funded by a Ph.D. Studentship from Fundação para a Ciência e Tecnologia (FCT), Portugal (SFRH/BD/48532/2008), and by a research grant from Fundacão Calouste Gulbenkian, Portugal (Project SDH49). A.B. Abecasis was funded by a postdoctoral fellowship from FCT (SFRH/BPD/65605/2009) and by an Investigator FCT Starting Researcher Contract.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVirology. 2018 Sep;522:122-130. doi: 10.1016/j.virol.2018.07.002. Epub 2018 Jul 18pt_PT
dc.identifier.doi10.1016/j.virol.2018.07.002pt_PT
dc.identifier.issn0042-6822
dc.identifier.urihttp://hdl.handle.net/10400.18/6324
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/ Academic Presspt_PT
dc.relationSUSCEPTIBILIDADE DOS VÍRUS INFLUENZA AOS ANTIVIRAIS ESPECÍFICOS PARA A GRIPE
dc.relationCOMPARATIVE STUDY OF THE SELECTIVE PRESSURE, REPLICATION AND TRANSMISSION DYNAMICS OF HIV-1 SUBTYPES
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0042682218302046?via%3Dihubpt_PT
dc.subjectGenotypept_PT
dc.subjectGlobal Healthpt_PT
dc.subjectHumanspt_PT
dc.subjectInfluenza A viruspt_PT
dc.subjectInfluenza B viruspt_PT
dc.subjectInfluenza, Humanpt_PT
dc.subjectNeuraminidasept_PT
dc.subjectSequence Analysis, DNApt_PT
dc.subjectViral Proteinspt_PT
dc.subjectSelection, Geneticpt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.titleMolecular footprints of selective pressure in the neuraminidase gene of currently circulating human influenza subtypes and lineagespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSUSCEPTIBILIDADE DOS VÍRUS INFLUENZA AOS ANTIVIRAIS ESPECÍFICOS PARA A GRIPE
oaire.awardTitleCOMPARATIVE STUDY OF THE SELECTIVE PRESSURE, REPLICATION AND TRANSMISSION DYNAMICS OF HIV-1 SUBTYPES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F48532%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F65605%2F2009/PT
oaire.citation.endPage130pt_PT
oaire.citation.startPage122pt_PT
oaire.citation.titleVirologypt_PT
oaire.citation.volume522pt_PT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctPolítica editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication9234051a-53c8-4503-b569-8dbc4d8a2ac9
relation.isProjectOfPublication559c5a8f-7b8f-4c8d-b560-9953238a9706
relation.isProjectOfPublication.latestForDiscovery9234051a-53c8-4503-b569-8dbc4d8a2ac9

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