Publication
Human biomonitoring studies contribution for better public health decisions
| dc.contributor.author | Louro, Henriqueta | |
| dc.contributor.author | Vasconcelos, Ana Luisa | |
| dc.contributor.author | Penque, Deborah | |
| dc.contributor.author | Silva, Maria João | |
| dc.date.accessioned | 2018-08-16T14:37:24Z | |
| dc.date.available | 2018-08-16T14:37:24Z | |
| dc.date.issued | 2018-07-04 | |
| dc.description.abstract | The use of chemicals in a wide spectrum of applications from biomedicine to agriculture has brought undeniable benefits to society. However, it is also important to assess, control and minimize potential costs, in terms of long-term impacts on human health and the environment quality. In order to enable chemicals risk assessment and management based on scientific evidence, it is crucial to know the real exposure of citizens to chemicals as well as their adverse effects on human health. In addition, within the framework of chemicals risk assessment, hazard characterization through in vitro and in vivo studies is also central. In this context, the team has developed biomonitoring and molecular epidemiology studies aimed at exploring interactions between occupational or environmental stressors and the human genome/proteome, as determinants of human diseases. Among these, the characterization of biological effects from occupational exposure to second-hand smoke and the effects of uranium mines and its residues on the population health will be presented to highlight their relevance for public health and environment policies. The results of an ongoing study focused on the genotoxicity of the chemical Di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate (DINCH), which has been applied as a non-aromatic plasticizer to replace other hazardous phthalate plasticizers will illustrate the additional need of toxicological studies for a comprehensive assessment of the potential adverse effects of chemicals on human health. Finally, the objectives of the European Biomonitoring Initiative - HBM4EU (https://www.hbm4eu.eu/) aimed at filling the knowledge gaps and promoting innovative approaches in the area of human exposure to chemicals will be presented, as an example of a multidisciplinary and integrative programme that is expected to support the formulation of better environment and health policies to protect human health. | pt_PT |
| dc.description.sponsorship | The HBM4EU project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 733032. | pt_PT |
| dc.description.version | N/A | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/5600 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Instituto Nacional de Saúde Doutor Ricardo Jorge, IP | pt_PT |
| dc.relation | European Human Biomonitoring Initiative | |
| dc.subject | Human Biomonitoring | pt_PT |
| dc.subject | Genotoxicidade Ambiental | pt_PT |
| dc.title | Human biomonitoring studies contribution for better public health decisions | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | European Human Biomonitoring Initiative | |
| oaire.awardURI | info:eu-repo/grantAgreement/EC/H2020/733032/EU | |
| oaire.citation.conferencePlace | Lisboa, Portugal | pt_PT |
| oaire.citation.title | Ciência 2018 - Encontro de Ciência e Tecnologia em Portugal, 4 julho 2018 | pt_PT |
| oaire.fundingStream | H2020 | |
| project.funder.identifier | http://doi.org/10.13039/501100008530 | |
| project.funder.name | European Commission | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
| relation.isProjectOfPublication | 6815dc2d-ef7e-4535-8dd3-5193c8bffba5 | |
| relation.isProjectOfPublication.latestForDiscovery | 6815dc2d-ef7e-4535-8dd3-5193c8bffba5 |