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Pseudomonas aeruginosa: One Health approach to deciphering hidden relationships in Northern Portugal

2025-02-13Artigo científico Acesso restrito
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dc.contributor.authorde Sousa, Telma
dc.contributor.authorMachado, Sandro
dc.contributor.authorCaniça, Manuela
dc.contributor.authorRamos, Miguel J.N.
dc.contributor.authorSantos, Daniela
dc.contributor.authorRibeiro, Miguel
dc.contributor.authorHébraud, Michel
dc.contributor.authorIgrejas, Gilberto
dc.contributor.authorAlves, Olimpia
dc.contributor.authorCosta, Eliana
dc.contributor.authorSilva, Augusto
dc.contributor.authorLopes, Ricardo
dc.contributor.authorPoeta, Patrícia
dc.date.accessioned2026-02-05T11:43:19Z
dc.date.available2026-02-05T11:43:19Z
dc.date.issued2025-02-13
dc.description.abstractAims: Antimicrobial resistance in Pseudomonas aeruginosa represents a major global challenge in public and veterinary health, particularly from a One Health perspective. This study aimed to investigate antimicrobial resistance, the presence of virulence genes, and the genetic diversity of P. aeruginosa isolates from diverse sources. Methods and results: The study utilized antimicrobial susceptibility testing, genomic analysis for resistance and virulence genes, and multilocus sequence typing to characterize a total of 737 P. aeruginosa isolates that were collected from humans, domestic animals, and aquatic environments in Northern Portugal. Antimicrobial resistance profiles were analyzed, and genomic approaches were employed to detect resistance and virulence genes. The study found a high prevalence of multidrug-resistant isolates, including high-risk clones such as ST244 and ST446, particularly in hospital sources and wastewater treatment plants. Key genes associated with resistance and virulence, including efflux pumps (e.g. MexA and MexB) and secretion systems (T3SS and T6SS), were identified. Conclusions: This work highlights the intricate dynamics of multidrug-resistant P. aeruginosa across interconnected ecosystems in Northern Portugal. It underscores the importance of genomic studies in revealing the mechanisms of resistance and virulence, contributing to the broader understanding of resistance dynamics and informing future mitigation strategies.eng
dc.description.sponsorshipThis research was funded by FCT (Fundação para a Ciência e a Tecnologia) related to a Ph.D. grant through the reference 2020.05332.BD, and the projects UI/00 772 and LAP/0059/2020.
dc.identifier.citationJ Appl Microbiol. 2025 Feb 3;136(2):lxaf037. doi: 10.1093/jambio/lxaf037
dc.identifier.doi10.1093/jambio/lxaf037
dc.identifier.eissn1365-2672
dc.identifier.issn1364-5072
dc.identifier.pmid39947205
dc.identifier.urihttp://hdl.handle.net/10400.18/10814
dc.language.isoeng
dc.peerreviewedyes
dc.publisherOxford University Press
dc.relationVeterinary and Animal Science Research Centre
dc.relationAssociate Laboratory for Animal and Veterinary Sciences
dc.relation.hasversionhttps://academic.oup.com/jambio/article-abstract/136/2/lxaf037/8011545?redirectedFrom=fulltext
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectPseudomonas aeruginosa
dc.subjectOne Health
dc.subjectantimicrobial resistance
dc.subjectPortugal
dc.subjectAntimicrobial Resistance
dc.subjectVirulence
dc.subjectMolecular Epidemiology
dc.subjectResistência aos Antimicrobianos
dc.titlePseudomonas aeruginosa: One Health approach to deciphering hidden relationships in Northern Portugaleng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleVeterinary and Animal Science Research Centre
oaire.awardTitleAssociate Laboratory for Animal and Veterinary Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00772%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0059%2F2020/PT
oaire.citation.issue2
oaire.citation.startPagelxaf037
oaire.citation.titleJournal of Applied Microbiology
oaire.citation.volume136
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublicatione683cb7c-d293-4738-83c6-c3c95d798e4d
relation.isProjectOfPublication93de5af7-dedc-4696-ae11-592584b020a8
relation.isProjectOfPublication.latestForDiscoverye683cb7c-d293-4738-83c6-c3c95d798e4d

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