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The Usefulness of Early Effect Biomarkers in Monitoring Occupational Exposure to Hexavalent Chromium

2019-10-25Conference object Restricted access
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dc.contributor.authorAfonso, Catarina
dc.contributor.authorGomes, Bruno Costa
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorNogueira, Ana
dc.contributor.authorPinhal, Hermínia
dc.contributor.authorReis, S.
dc.contributor.authorVentura, Célia
dc.contributor.authorLadeira, Carina
dc.contributor.authorRibeiro, Edna
dc.contributor.authorSantonen, Tiina
dc.contributor.authorViegas, Susana
dc.contributor.authorSilva, Maria João
dc.date.accessioned2020-07-15T18:25:32Z
dc.date.available2020-07-15T18:25:32Z
dc.date.issued2019-10-25
dc.description.abstractIntroduction: In the frame of the Project HBM4EU (https://www.hbm4eu.eu/) a biomonitoring study is being conducted across Europe to characterize occupational exposure to hexavalent chromium [Cr(VI)], a recognized human lung carcinogen. Herein we present the results of biomarkers of exposure and effect characterized in a group of workers from a Portuguese aircraft maintenance company, where Cr(VI) replacement is not expected in the near future. Methods: All participants signed an informed consent and responded to a questionnaire to collect contextual information. Cr(VI) exposure was assessed by the analysis of personal air samples; total Cr was measured in urine and blood samples from 50 workers and 26 controls. The effects biomarkers included the alkaline comet assay and the cytokinesis-block micronucleus assay in blood in leukocytes. Results: The concentrations of Cr in the air samples were variable, depending on the activities performed. Noteworthy, workers engaged in painting exterior surfaces with Cr(VI)-reach paints were exposed to the highest Cr(VI) levels. Results from biomonitoring confirmed the occurrence of internal exposure. Furthermore, significantly increased micronuclei frequencies (p < 0.001, Fisher’s exact test) and DNA damage levels were identified in leukocytes from workers comparatively to controls. Interestingly, among the painters showed up a group of 6 workers who were exposed to a mixture of Cr, organic solvents, silica, and other chemicals and who displayed an elevated level of micronucleated cells comparatively to matched controls. Conclusions: An association between Cr(VI) exposure and genotoxicity biomarkers was found, raising concern about a potentially increased cancer risk. Furthermore, these results suggest that the effect biomarkers selected are useful to strengthen the exposure data, in that more exposed or vulnerable groups can be more reliably detected. This is relevant to allow the prioritization of occupational hygiene and risk management measures implementation in the workplace.pt_PT
dc.description.sponsorshipWork co-funded by the H2020 HBM4EU project (GA 733032).pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7057
dc.language.isoengpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.subjectHexavalent Chromiumpt_PT
dc.subjectOccupational Exposurept_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectHuman Biomonitoring
dc.subjectGenotoxicidade Ambiental
dc.titleThe Usefulness of Early Effect Biomarkers in Monitoring Occupational Exposure to Hexavalent Chromiumpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.title2nd Workshop on Human Biomonitoring in Portugal (2nd HBM-PT), 25 October 2019pt_PT
oaire.fundingStreamH2020
person.familyNameLouro
person.familyNameVentura
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameCélia
person.givenNameMaria Joao
person.identifier157627
person.identifier2056460
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id6116-89BA-C617
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-0637-2222
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationfa89f42b-12a4-47bd-a4fb-0f65cbc06885
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscoverya7763685-7c34-468d-b958-9dd0aca66db4
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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