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HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium

2022-08-18Journal article Open access
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dc.contributor.authorTavares, Ana
dc.contributor.authorAimonen, Kukka
dc.contributor.authorNdaw, Sophie
dc.contributor.authorFučić, Aleksandra
dc.contributor.authorCatalán, Julia
dc.contributor.authorDuca, Radu Corneliu
dc.contributor.authorGodderis, Lode
dc.contributor.authorGomes, Bruno C.
dc.contributor.authorJanasik, Beata
dc.contributor.authorLadeira, Carina
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorNamorado, Sónia
dc.contributor.authorNieuwenhuyse, An Van
dc.contributor.authorNorppa, Hannu
dc.contributor.authorScheepers, Paul
dc.contributor.authorVentura, Célia
dc.contributor.authorVerdonck, Jelle
dc.contributor.authorViegas, Susana
dc.contributor.authorWasowicz, Wojciech
dc.contributor.authorSantonen, Tiina
dc.contributor.authorSilva, M.J.
dc.contributor.authoron behalf of the HBM4EU Chromates Study Team
dc.date.accessioned2022-11-02T13:55:04Z
dc.date.available2022-11-02T13:55:04Z
dc.date.issued2022-08-18
dc.descriptionThis article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention?pt_PT
dc.description.abstractA study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure to Cr(VI). Herein we present the results of biomarkers of genotoxicity and oxidative stress, including micronucleus analysis in lymphocytes and reticulocytes, the comet assay in whole blood, and malondialdehyde and 8-oxo-2'-deoxyguanosine in urine. Workers from several Cr(VI)-related industrial activities and controls from industrial (within company) and non-industrial (outwith company) environments were included. The significantly increased genotoxicity (p = 0.03 for MN in lymphocytes and reticulocytes; p < 0.001 for comet assay data) and oxidative stress levels (p = 0.007 and p < 0.001 for MDA and 8-OHdG levels in pre-shift urine samples, respectively) that were detected in the exposed workers over the outwith company controls suggest that Cr(VI) exposure might still represent a health risk, particularly, for chrome painters and electrolytic bath platers, despite the low Cr exposure. The within-company controls displayed DNA and chromosomal damage levels that were comparable to those of the exposed group, highlighting the relevance of considering all industry workers as potentially exposed. The use of effect biomarkers proved their capacity to detect the early biological effects from low Cr(VI) exposure, and to contribute to identifying subgroups that are at higher risk. Overall, this study reinforces the need for further re-evaluation of the occupational exposure limit and better application of protection measures. However, it also raised some additional questions and unexplained inconsistencies that need follow-up studies to be clarified.pt_PT
dc.description.sponsorshipThis project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no. 733032 and received co-funding from the author’s organizations and/or Ministries.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationToxics. 2022 Aug 18;10(8):483. doi: 10.3390/toxics10080483pt_PT
dc.identifier.doi10.3390/toxics10080483pt_PT
dc.identifier.issn2305-6304
dc.identifier.urihttp://hdl.handle.net/10400.18/8293
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://www.mdpi.com/2305-6304/10/8/483pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHexavalent Chromiumpt_PT
dc.subjectChromiumpt_PT
dc.subjectBiomonitoringpt_PT
dc.subjectEffect Biomarkerspt_PT
dc.subjectMicronucleipt_PT
dc.subject8-OHdGpt_PT
dc.subjectMDApt_PT
dc.subjectOccupational Exposurept_PT
dc.subjectComet Assaypt_PT
dc.subjectOxidative Stresspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectEuropean Human Biomonitoring Initiativept_PT
dc.subjectHBM4EUpt_PT
dc.subjectEuropept_PT
dc.subjectCrómiopt_PT
dc.subjectExposição Ocupacionalpt_PT
dc.subjectMicronúcleospt_PT
dc.subjectBiomonitorizaçaopt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.subjectBiomarcadores de Efeitopt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.subjectEuropa
dc.titleHBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromiumpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.issue8pt_PT
oaire.citation.startPage483pt_PT
oaire.citation.titleToxicspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStreamH2020
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person.familyNameFernandes Ladeira
person.familyNameLouro
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person.givenNameBEATA
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person.givenNameSónia
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person.givenNamePaul
person.givenNameCélia
person.givenNameJelle
person.givenNameSusana
person.givenNameWojciech
person.givenNameTiina
person.givenNameMaria Joao
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project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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