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Effects of iron oxide nanoparticles: Cytotoxicity, genotoxicity, developmental toxicity, and neurotoxicity

2015-03Journal article Restricted access
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dc.contributor.authorValdiglesias, V.
dc.contributor.authorKiliç, G.
dc.contributor.authorCosta, C.
dc.contributor.authorFernández-Bertólez, N
dc.contributor.authorPásaro, E.
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorLaffon, B.
dc.date.accessioned2016-02-16T17:58:05Z
dc.date.available2018-01-01T01:30:10Z
dc.date.issued2015-03
dc.description.abstractIron oxide nanoparticles (ION) with superparamagnetic properties hold great promise for use in various biomedical applications; specific examples include use as contrast agents for magnetic resonance imaging, in targeted drug delivery, and for induced hyperthermia cancer treatments. Increasing potential applications raise concerns over their potential effects on human health. Nevertheless, very little is currently known about the toxicity associated with exposure to these nanoparticles at different levels of biological organization. This article provides an overview of recent studies evaluating ION cytotoxicity, genotoxicity, developmental toxicity and neurotoxicity. Although the results of these studies are sometimes controversial, they generally indicate that surface coatings and particle size seem to be crucial for the observed ION-induced effects, as they are critical determinants of cellular responses and intensity of effects, and influence potential mechanisms of toxicity. The studies also suggest that some ION are safe for certain biomedical applications, while other uses need to be considered more carefully. Overall, the available studies provide insufficient evidence to fully assess the potential risks for human health related to ION exposure. Additional research in this area is required including studies on potential long-term effects.pt_PT
dc.identifier.citationEnviron Mol Mutagen. 2015 Mar;56(2):125-48. doi: 10.1002/em.21909. Epub 2014 Sep 11.pt_PT
dc.identifier.doi10.1002/em.21909pt_PT
dc.identifier.issn0893-6692
dc.identifier.urihttp://hdl.handle.net/10400.18/3351
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/em.21909/fullpt_PT
dc.subjectIron Oxide Nanoparticlespt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectGenotoxicitypt_PT
dc.subjectNanoparticlespt_PT
dc.subjectDevelopmental Toxicitypt_PT
dc.subjectNeurotoxicitypt_PT
dc.subjectToxicologiapt_PT
dc.subjectGenotoxicidade Ambiental
dc.subjectAr e Saúde Ocupacional
dc.titleEffects of iron oxide nanoparticles: Cytotoxicity, genotoxicity, developmental toxicity, and neurotoxicitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage148pt_PT
oaire.citation.startPage125pt_PT
oaire.citation.titleEnvironmental and Molecular Mutagenesispt_PT
oaire.citation.volume56(2)pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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