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Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors

2021-12-10Journal article Open access
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dc.contributor.authorTeixeira-Gomes, Armanda
dc.contributor.authorLaffon, Blanca
dc.contributor.authorValdiglesias, Vanessa
dc.contributor.authorGostner, Johanna M.
dc.contributor.authorFelder, Thomas
dc.contributor.authorCosta, Carla
dc.contributor.authorMadureira, Joana
dc.contributor.authorFuchs, Dietmar
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorCosta, Solange
dc.date.accessioned2022-07-06T15:50:40Z
dc.date.available2022-07-06T15:50:40Z
dc.date.issued2021-12-10
dc.description(This article belongs to the Special Issue Tryptophan Metabolism in Health and Disease)pt_PT
dc.description.abstractAgeing is accompanied with a decline in several physiological systems. Frailty is an age-related syndrome correlated to the loss of homeostasis and increased vulnerability to stressors, which is associated with increase in the risk of disability, comorbidity, hospitalisation, and death in older adults. The aim of this study was to understand the relationship between frailty syndrome, immune activation, and oxidative stress. Serum concentrations of vitamins A and E were also evaluated, as well as inflammatory biomarkers (CRP and IL-6) and oxidative DNA levels. A group of Portuguese older adults (≥65 years old) was engaged in this study and classified according to Fried's frailty phenotype. Significant increases in the inflammatory mediators (CRP and IL-6), neopterin levels, kynurenine to tryptophan ratio (Kyn/Trp), and phenylalanine to tyrosine ratio (Phe/Tyr), and significant decreases in Trp and Tyr concentrations were observed in the presence of frailty. IL-6, neopterin, and Kyn/Trp showed potential as predictable biomarkers of frailty syndrome. Several clinical parameters such as nutrition, dependency scales, and polypharmacy were related to frailty and, consequently, may influence the associations observed. Results obtained show a progressive immune activation and production of pro-inflammatory molecules in the presence of frailty, agreeing with the inflammageing model. Future research should include different dimensions of frailty, including psychological, social, biological, and environmental factors.pt_PT
dc.description.sponsorshipATG: J.M. and S.C. are supported by Fundação para a Ciência e Tecnologia (FCT-MCTES), and the European Social Fund, through Programa Operacional Capital Humano (POCH), under the grants SFRH/BD/121802/2016, SFRH/BPD/115112/2016 and SFRH/BPD/100948/2014, respectively. This research was supported by Ministerio de Ciencia e Innovación (PID2020-113788RB-I00) and Ministerio de Educación, Cultura y Deporte (BEAGAL18/00142, to V.V.)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAntioxidants (Basel). 2021 Dec 10;10(12):1975. doi: 10.3390/antiox10121975pt_PT
dc.identifier.doi10.3390/antiox10121975pt_PT
dc.identifier.issn2076-3921
dc.identifier.urihttp://hdl.handle.net/10400.18/8072
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationAn exposome approach to frailty in older adults
dc.relationEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
dc.relationNew molecular biomarkers for early detection and prevention of frailty in older adults
dc.relation.publisherversionhttps://www.mdpi.com/2076-3921/10/12/1975pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCRP and IL-6pt_PT
dc.subjectKyn/Trppt_PT
dc.subjectPhe/Tyrpt_PT
dc.subjectFrailtypt_PT
dc.subjectModifiable Risk Factorspt_PT
dc.subjectNeopterinpt_PT
dc.subjectNitritept_PT
dc.subjectOxi-Immune Markerspt_PT
dc.subjectOxidative DNA Damagept_PT
dc.subjectVitamin Apt_PT
dc.subjectVitamin Ept_PT
dc.titleExploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factorspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAn exposome approach to frailty in older adults
oaire.awardTitleEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
oaire.awardTitleNew molecular biomarkers for early detection and prevention of frailty in older adults
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F121802%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F115112%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F100948%2F2014/PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1975pt_PT
oaire.citation.titleAntioxidantspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStreamPOR_NORTE
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isProjectOfPublication.latestForDiscovery0c38fa63-8890-47d4-b3d3-1aa47f53b966

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