Repository logo
 
Publication

Regulation of the Alternative Splicing of Tumor-Related RAC1b by Signal Transduction Pathways

2018-11Conference object Restricted access
Simple item page
dc.contributor.authorGonçalves, Vânia
dc.contributor.authorMatos, Paulo
dc.contributor.authorPereira, Joana
dc.contributor.authorHenriques, Andreia
dc.contributor.authorJordan, Peter
dc.date.accessioned2019-02-14T12:20:47Z
dc.date.available2020-06-01T00:30:21Z
dc.date.issued2018-11
dc.description.abstractDistinct genetic subtypes have been described in colon cancer, one of which involves overexpression of RAC1b, a variant generated by alternative splicing. Aberrant splicing is known to occur in cancer and can be caused by mutation in a gene or splicing factor but also represents a dynamic response to oncogeneinduced cellular signaling and in this case it may be pharmacologically targeted. Here we explore how signaling pathways are involved in the deregulation of alternative RAC1b splicing in colorectal tumor cells.pt_PT
dc.description.sponsorshipThis work was supported by the Fundação para a Ciência e Tecnologia, Portugal and Association Maratona da Saúde.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.doi10.1097/MD.0000000000015772
dc.identifier.urihttp://hdl.handle.net/10400.18/5822
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectColon Cancerpt_PT
dc.subjectAlternative Splicingpt_PT
dc.subjectRAC1bpt_PT
dc.subjectSignal Transductuionpt_PT
dc.subjectVias de Transdução de Sinal e Patologias Associadaspt_PT
dc.titleRegulation of the Alternative Splicing of Tumor-Related RAC1b by Signal Transduction Pathwayspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePorto, Portugalpt_PT
oaire.citation.title22ª reunião anual da Sociedade Portuguesa de Genética Humana, 15-17 novembro 2018pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Regulation of the Alternative Splicing of Tumor-Related.pdf
Size:
226.03 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DGH - Apresentações orais em encontros internacionais