Phylogenomic characterization of the causative strain of one of the largest worldwide outbreaks of Legionnaires’ disease occurred in Portugal in 2014

Borges, Vítor; Nunes, Alexandra; Sampaio, Daniel; Vieira, Luís; Gomes, João Paulo

http://hdl.handle.net/10400.18/4629

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Background: Legionnaires’ disease (LD) is a severe pneumonia with a case fatality rate of 8–12%. Transmission usually occurs by inhalation of aerosols or aspiration of water containing Legionella spp, where L. pneumophila serogroup 1 accounts for most of the occasional outbreaks. The world’s second largest outbreak of LD occurred in 2014 in Vila Franca de Xira, Portugal, yielding more than 400 cases and 14 deaths. The L. pneumophila causative strain is from serogroup 1 and displays the novel sequence type (ST) ST1905. Here, we described how whole-genome sequencing (WGS) / Bioinformatics was used for real-time investigation of this LD outbreak as well as for integrating the genetic backbone of the causative strain in the frame of the species phylogeny and diversity.