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Urinary Estrogen Metabolites and Self-Reported Infertility in Women Infected with Schistosoma haematobium

2014-05Artigo científico Acesso aberto
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dc.contributor.authorSantos, J.
dc.contributor.authorGouveia, M.J.
dc.contributor.authorVale, N.
dc.contributor.authorDelgado, M. de L.
dc.contributor.authorGonçalves, A.
dc.contributor.authorda Silva, J.M.
dc.contributor.authorOliveira, C.
dc.contributor.authorXavier, P.
dc.contributor.authorGomes, P.
dc.contributor.authorSantos, L.L.
dc.contributor.authorLopes, C.
dc.contributor.authorBarros, A.
dc.contributor.authorRinaldi, G.
dc.contributor.authorBrindley, P.J.
dc.contributor.authorda Costa, J.M.
dc.contributor.authorSousa, M.
dc.contributor.authorBotelho, M.C.
dc.date.accessioned2014-06-12T14:32:56Z
dc.date.available2014-06-12T14:32:56Z
dc.date.issued2014-05
dc.description.abstractSchistosomiasis is a neglected tropical disease, endemic in 76 countries, that afflicts more than 240 million people. The impact of schistosomiasis on infertility may be underestimated according to recent literature. Extracts of Schistosoma haematobium include estrogen-like metabolites termed catechol-estrogens that down regulate estrogen receptors alpha and beta in estrogen responsive cells. In addition, schistosome derived catechol-estrogens induce genotoxicity that result in estrogen-DNA adducts. These catechol estrogens and the catechol-estrogen-DNA adducts can be isolated from sera of people infected with S. haematobium. The aim of this study was to study infertility in females infected with S. haematobium and its association with the presence of schistosome-derived catechol-estrogens.por
dc.identifier.citationPLoS One. 2014 May 21;9(5):e96774. doi: 10.1371/journal.pone.0096774. eCollection 2014por
dc.identifier.issn1932-6203
dc.identifier.otherdoi:10.1371/journal.pone.0096774
dc.identifier.urihttp://hdl.handle.net/10400.18/2309
dc.language.isoengpor
dc.publisherPublic Library of Sciencepor
dc.relation.publisherversionhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0096774por
dc.subjectSchistosoma Haematobiumpor
dc.subjectEstrogen Metabolitespor
dc.subjectInfertilitypor
dc.titleUrinary Estrogen Metabolites and Self-Reported Infertility in Women Infected with Schistosoma haematobiumpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titlePLoS Onepor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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