Urinary Estrogen Metabolites and Self-Reported Infertility in Women Infected with Schistosoma haematobium

Schistosomiasis is a neglected tropical disease, endemic in 76 countries, that afflicts more than 240 million people. The impact of schistosomiasis on infertility may be underestimated according to recent literature. Extracts of Schistosoma haematobium include estrogen-like metabolites termed catechol-estrogens that down regulate estrogen receptors alpha and beta in estrogen responsive cells. In addition, schistosome derived catechol-estrogens induce genotoxicity that result in estrogen-DNA adducts. These catechol estrogens and the catechol-estrogen-DNA adducts can be isolated from sera of people infected with S. haematobium. The aim of this study was to study infertility in females infected with S. haematobium and its association with the presence of schistosome-derived catechol-estrogens.

Palavras-chave

Schistosoma Haematobium Estrogen Metabolites Infertility

URI

http://hdl.handle.net/10400.18/2309

Citação

PLoS One. 2014 May 21;9(5):e96774. doi: 10.1371/journal.pone.0096774. eCollection 2014

Editora

Public Library of Science

Coleções

DPSPDNT - Artigos em revistas internacionais

Ver registo completo