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Mycotoxins in adult population from Portugal: Overall results and determinants of exposure

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dc.contributor.authorVidal, Arnau
dc.contributor.authorDe Saeger, Sarah
dc.contributor.authorSarah, De Saeger
dc.contributor.authorNunes, Carla
dc.contributor.authorTorres, D.
dc.contributor.authorGoios, A.
dc.contributor.authorLopes, Carla
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorAlvito, Paula
dc.contributor.authorDe Boevre, Marthe
dc.date.accessioned2020-06-07T16:21:16Z
dc.date.available2020-06-07T16:21:16Z
dc.date.issued2019-09
dc.description.abstractHuman biomonitoring (HBM) is recognized as an important tool to assess the Human exposure to chemicals, contributing to describe trends and patterns of exposure over time and to identify population groups that could be under risk. Mycotoxins, fungi secondary metabolites that produce toxic effects in humans, are important compounds found in foods usually consumed worldwide in a daily basis. In Portugal, scarce data are available regarding exposure to mycotoxins and the determinants of this exposure. In the scope of the National Food, Nutrition, and Physical Activity Survey of the Portuguese General Population (2015-2016), 24h-urine samples from 94 participants were analyzed by liquid chromatography–mass spectrometry (LC-MS/MS) for the simultaneous determination of 37 urinary mycotoxins’ biomarkers and data obtained used to estimate the probable daily intake as well as the risk characterization applying the Hazard Quotient approach. Participants performed two face-to-face interviews and dietary intake was obtained by two non-consecutive 24-hours recalls with a time interval between 8 and 15 days, complemented with a Food Propensity Questionnaire. Results revealed the exposure of Portuguese population to zearalenone, deoxynivalenol, ochratoxin A, alternariol, citrinin and fumonisin B1 through the quantification in 24h urine and first-morning urine paired samples. Risk characterization data revealed a potential concern to some reported mycotoxins since the reference intake values were exceeded by some of the considered participants. The present study generated, for the first time and within a HBM study, reliable data on internal exposure to mycotoxins at individual level for the Portuguese population. These data were crucial to characterize the determinants of exposure and to support risk managers to establish preventive policy measures that contribute to ensure the public health protection.pt_PT
dc.description.sponsorshipThis research was performed with the financial support to CESAM (UID/AMB/50017/2019), to FCT/MEC through national funds, and the co-funding by the FEDER, within the PT2020 Partnership Agreement and Compete 2020. This research was also supported by the project MYTOX-SOUTH, Ghent University Global Minds programme. IAN-AF national survey was funded by the EEA Grants Program, Public Health Initiatives (PT06 - 000088SI3).pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/6937
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectChemicals Exposurept_PT
dc.subjectMycotoxinspt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectToxicologiapt_PT
dc.subjectAvaliação de Riscopt_PT
dc.subjectSaúde Humanapt_PT
dc.subjectPortugalpt_PT
dc.titleMycotoxins in adult population from Portugal: Overall results and determinants of exposurept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT (2019)
oaire.citation.conferencePlaceAveiro, Portugalpt_PT
oaire.citation.title3rd International Conference on Food Contaminants (ICFC 2019): Challenges in Risk Assessment, 26-27 September 2019pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublicationf076fef9-580b-485a-9a0e-c5a599424c6e
relation.isProjectOfPublication.latestForDiscoveryf076fef9-580b-485a-9a0e-c5a599424c6e

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