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Determinants of fatal outcome in patients admitted to intensive care units with influenza, European Union 2009–2017

2019-10-29Journal article Open access
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dc.contributor.authorPenttinen, Pasi
dc.contributor.authorSnacken, René
dc.contributor.authorLyytikäinen, Outi
dc.contributor.authorIkonen, Niina
dc.contributor.authorMelillo, Tanya
dc.contributor.authorMelillo, Jackie M.
dc.contributor.authorStaroňová, Edita
dc.contributor.authorMikas, Ján
dc.contributor.authorPopow-Kraupp, Theresia
dc.contributor.authorOrta Gomes, Carlos M.
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorSlezák, Pavel
dc.contributor.authorKynčl, Jan
dc.contributor.authorMeijer, Adam
dc.contributor.authorVan Gageldonk-Lafeber, Arianne B.
dc.contributor.authorDomegan, Lisa
dc.contributor.authorO’Donnell, Joan
dc.contributor.authorLupulescu, Emilia
dc.contributor.authorPopovici, Odette
dc.contributor.authorCarnahan, Annasara
dc.contributor.authorBrytting, Mia
dc.contributor.authorDelgado-Sanz, Concepción
dc.contributor.authorOliva Domínguez, Jesús A.
dc.contributor.authorLarrauri, Amparo
dc.contributor.authorHubert, Bruno
dc.contributor.authorBonmarin, Isabelle
dc.contributor.authorGomes Dias, Joana
dc.contributor.authorAdlhoch, Cornelia
dc.date.accessioned2020-05-08T09:58:52Z
dc.date.available2020-05-08T09:58:52Z
dc.date.issued2019-10-29
dc.descriptionFree PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32258201/
dc.description.abstractBackground: Morbidity, severity, and mortality associated with annual influenza epidemics are of public health concern. We analyzed surveillance data on hospitalized laboratory-confirmed influenza cases admitted to intensive care units to identify common determinants for fatal outcome and inform and target public health prevention strategies, including risk communication. Methods: We performed a descriptive analysis and used Poisson regression models with robust variance to estimate the association of age, sex, virus (sub)type, and underlying medical condition with fatal outcome using European Union data from 2009 to 2017. Results: Of 13 368 cases included in the basic dataset, 2806 (21%) were fatal. Age ≥40 years and infection with influenza A virus were associated with fatal outcome. Of 5886 cases with known underlying medical conditions and virus A subtype included in a more detailed analysis, 1349 (23%) were fatal. Influenza virus A(H1N1)pdm09 or A(H3N2) infection, age ≥60 years, cancer, human immunodeficiency virus infection and/or other immune deficiency, and heart, kidney, and liver disease were associated with fatal outcome; the risk of death was lower for patients with chronic lung disease and for pregnant women. Conclusions: This study re-emphasises the importance of preventing influenza in the elderly and tailoring strategies to risk groups with underlying medical conditions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOpen Forum Infect Dis. 2019 Oct 29;6(11):ofz462. doi: 10.1093/ofid/ofz462. eCollection 2019 Nov.pt_PT
dc.identifier.doi10.1093/ofid/ofz462pt_PT
dc.identifier.issn2328-8957
dc.identifier.urihttp://hdl.handle.net/10400.18/6612
dc.language.isoengpt_PT
dc.publisherOxford University Press/ on behalf of Infectious Diseases Society of America
dc.relation.publisherversionhttps://academic.oup.com/ofid/article/6/11/ofz462/5608594pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectInfluenza Viruspt_PT
dc.subjectIntensive Care Unitspt_PT
dc.subjectUnderlying Medical Conditionspt_PT
dc.subjectAgept_PT
dc.subjectEUpt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.titleDeterminants of fatal outcome in patients admitted to intensive care units with influenza, European Union 2009–2017pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11pt_PT
oaire.citation.startPageofz462pt_PT
oaire.citation.titleOpen Forum Infectious Diseasespt_PT
oaire.citation.volume6pt_PT
rcaap.embargofctDe acordo com o editor online da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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