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Publicação
Standardized Phylogenetic Classification of Human Respiratory Syncytial Virus below the Subgroup Level
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| 1.88 MB | Adobe PDF |
Orientador(es)
Resumo(s)
A globally implemented unified phylogenetic classification for human respiratory syncytial virus (HRSV) below the subgroup level remains elusive. We formulated global consensus of HRSV classification on the basis of the challenges and limitations of our previous proposals and the future of genomic surveillance. From a high-quality curated dataset of 1,480 HRSV-A and 1,385 HRSV-B genomes submitted to GenBank and GISAID (https://www.gisaid.org) public sequence databases through March 2023, we categorized HRSV-A/B sequences into lineages based on phylogenetic clades and amino acid markers. We defined 24 lineages within HRSV-A and 16 within HRSV-B and provided guidelines for defining prospective lineages. Our classification demonstrated robustness in its applicability to both complete and partial genomes. We envision that this unified HRSV classification proposal will strengthen HRSV molecular epidemiology on a global scale.
Descrição
Palavras-chave
F G HRSV RSV Classification Epidemiology Evolution Genome Genotype Glycoprotein Lineage Orthopneumovirus Phylogeny Respiratory Infections Respiratory Syncytial Virus Surveillance Infecções Respiratórias
Contexto Educativo
Citação
Emerg Infect Dis. 2024 Aug;30(8):1631-1641. doi: 10.3201/eid3008.240209
Editora
Centers for Disease Control and Prevention