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Hepatitis B and C prevalence in Portugal: disparity between the general population and high-risk groups

2016-06Journal article Restricted access
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dc.contributor.authorCarvalhana, S.C.
dc.contributor.authorLeitão, J.
dc.contributor.authorAlves, A.C.
dc.contributor.authorBourbon, M.
dc.contributor.authorCortez-Pinto, H.
dc.date.accessioned2016-09-28T13:07:44Z
dc.date.available2016-09-28T13:07:44Z
dc.date.issued2016-06
dc.description.abstractBackground and aims: The prevalence of anti-HCV and HBsAg in Portugal has been shown to be elevated in high-risk groups, such as intravenous drug-users and incarcerated individuals. However, in the general population, prevalence remains largely unknown. The aims of this study were to estimate the prevalence of anti-HCV and HBsAg in the general Portuguese population and identify associated risk factors. Materials and methods: We carried out a nationwide, population-based cross-sectional study of adults resident in mainland Portugal. Serology for HBsAg, anti-HBc, anti-HBs, and anti-HCV was performed. Anti-HCV-positive individuals were tested for HCV RNA by PCR. Results: Of 1685 participants, 50.6% were men, mean age 50.2±18.3 years. In terms of hepatitis C, the prevalence of anti-HCV was 0.54% [95% confidence interval (CI): 0.2–0.9] and 0.12% (95% CI: 0.0–0.3) were viremic, with peak prevalence among individuals 35–64 years of age (0.8%), men (0.8%), and individuals from Lisbon and Tagus Valley region (1.9%). In terms of hepatitis B, the estimated prevalence of HBsAg was 1.45% (95% CI: 0.9–2.0). A higher prevalence was found in individuals who were 35–64 years old (2.2%), in men (2.5%), and in the Northern region (2.6%). The presence of positive serological markers of hepatitis C virus and hepatitis B virus infection did not correlate with elevated aminotransferases, race, place of birth, and alcohol consumption. Conclusion: These results suggest a low endemicity for both hepatitis B and hepatitis C in the general population, in contrast to a very high prevalence in risk groups, thus suggesting that targeted screening to high-risk groups may be more cost-effective than general population screening.pt_PT
dc.description.sponsorshipThe present study received grants from Gilead Foundation and Gilead Genesis, Roche Farmacêutica, CEREGA, and a grant from the Portuguese Association for the Study of the Liver (APEF).
dc.identifier.citationEur J Gastroenterol Hepatol. 2016 Jun;28(6):640-4. doi: 10.1097/MEG.0000000000000608pt_PT
dc.identifier.doi10.1097/MEG.000000000000060pt_PT
dc.identifier.issn0954-691X
dc.identifier.urihttp://hdl.handle.net/10400.18/3982
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWolters Kluwer Health/Lippincott, Williams & Wilkinspt_PT
dc.relation.publisherversionhttp://journals.lww.com/eurojgh/pages/articleviewer.aspx?year=2016&issue=06000&article=00005&type=abstractpt_PT
dc.subjectChronic Hepatitis Bpt_PT
dc.subjectChronic Hepatitis Cpt_PT
dc.subjectGeneral Populationpt_PT
dc.subjectPortugalpt_PT
dc.subjectPrevalencept_PT
dc.titleHepatitis B and C prevalence in Portugal: disparity between the general population and high-risk groupspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage644pt_PT
oaire.citation.startPage640pt_PT
oaire.citation.titleEuropean Journal of Gastroenterology and Hepatologypt_PT
oaire.citation.volume28(6)pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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