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Genetic alterations of ALK in high-risk neuroblastoma patients: a SIOPEN study
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Orientador(es)
Resumo(s)
Background: In neuroblastoma (NB), the ALK receptor tyrosine kinase can be
constitutively activated either through genomic amplification or activating point
mutations. We studied ALK genetic alterations in high-risk NB patients to determine
their frequency and prognostic impact.
Descrição
Palavras-chave
Neuroblastoma ALK Tumor Genomics Doenças Genéticas