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Schistosomiasis and infertility: what do we know?

2019-12Journal article Restricted access
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dc.contributor.authorRibeiro, Ana Rita
dc.contributor.authorLuis, Carla
dc.contributor.authorFernandes, Ruben
dc.contributor.authorBotelho, Monica C.
dc.date.accessioned2020-04-29T05:49:51Z
dc.date.available2020-04-29T05:49:51Z
dc.date.issued2019-12
dc.description.abstractThere is increasing attention on the complex interactions occurring between schistosome parasites and their hosts. However, little is known about the occurrence, epidemiology, and mechanisms of schistosomiasis-associated infertility. In this article, we argue that an in-depth understanding of the interplay between parasites and the host endocrine system may significantly enhance current knowledge of infertility in infected individuals. We discuss the basic hormonal mechanisms that may lead to the discovery of entirely novel anthelmintic interventions against schistosomiasis.pt_PT
dc.description.abstractHighlights: In spite of a plethora of epidemiological evidence supporting a key role for schistosome infection for infertility, little is known about the mechanisms of their association. To date, one of the few well characterized mechanisms by which schistosomes interact with their hosts is the estrogenic imbalance and downregulation of the estrogen receptor. Remarkably, our understanding of this mechanism has already been successfully studied in cancer-associated schistosomiasis. The relentless advancement in molecular studies, together with the discovery of novel biomarkers, provide unprecedented opportunities to investigate schistosomiasis and exploit parasite–host relationships for the development of novel strategies of disease control. There is increasing attention on the complex interactions occurring between schistosome parasites and their hosts. However, little is known about the occurrence, epidemiology, and mechanisms of schistosomiasis-associated infertility. In this article, we argue that an in-depth understanding of the interplay between parasites and the host endocrine system may significantly enhance current knowledge of infertility in infected individuals. We discuss the basic hormonal mechanisms that may lead to the discovery of entirely novel anthelmintic interventions against schistosomiasis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTrends Parasitol. 2019 Dec;35(12):964-971. doi: 10.1016/j.pt.2019.09.001. Epub 2019 Oct 14pt_PT
dc.identifier.doi10.1016/j.pt.2019.09.001pt_PT
dc.identifier.issn1471-4922
dc.identifier.urihttp://hdl.handle.net/10400.18/6553
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S147149221930234X?via%3Dihubpt_PT
dc.subjectCatechol-estrogenspt_PT
dc.subjectEstrogen Receptorspt_PT
dc.subjectEstrogenspt_PT
dc.subjectFemale Infertilitypt_PT
dc.subjectMale Infertilitypt_PT
dc.subjectSchistosomiasispt_PT
dc.titleSchistosomiasis and infertility: what do we know?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage971pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage964pt_PT
oaire.citation.titleTrends in Parasitologypt_PT
oaire.citation.volume35pt_PT
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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