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Are Portuguese population exposed to Zearalenone? A human biomonitoring study as a contribution to the risk assessment of an endocrine disruptor

2018-05Conference object Restricted access
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dc.contributor.authorMartins, Carla
dc.contributor.authorVidal, A.
dc.contributor.authorDe Saeger, Sarah
dc.contributor.authorAssunção, R.
dc.contributor.authorNunes, Carla
dc.contributor.authorTorres, D.
dc.contributor.authorGoios, A.
dc.contributor.authorLopes, Carla
dc.contributor.authorAlvito, P.
dc.contributor.authorDe Boevre, Marthe
dc.date.accessioned2019-02-19T15:01:24Z
dc.date.available2019-02-19T15:01:24Z
dc.date.issued2018-05
dc.description.abstractZearalenone (ZEN) is a mycotoxin that occurs widely in food commodities with particular incidence in cereals. Due to chemical structures similar to the endogenous oestrogen 17-β-estradiol, ZEN and its metabolites exert estrogenic toxicity. Therefore, it is crucial to assess ZEN exposure among the population and biomarker-driven research is a promising method to assess the human exposure. For this reason, ZEN metabolites such as α-zearalenol (α-ZEL), β-zearalenol (β-ZEL), α-zearalenal (α-ZAL), β-zearalenal (β-ZAL), zearalanone (ZAN) (phase I) and the glucuronides ZEN14GlcA, α-ZEL14GlcA and β-ZEL14Glc (phase II) were identified in biological fluids. With a potency factor of 60 relative to ZEN, α-ZEL is the most relevant metabolite in terms of human health. ZEN is characterized by a fast metabolism and excretion, therefore urine is the matrix commonly used to assess the exposure to this mycotoxin and its metabolites. To date, in Portugal, there is a lack of human studies to assess biomarkers of exposure to ZEN. Within the Scope of National Food, Nutrition, and Physical Activity Survey of the Portuguese General Population (2015-2016), 24h-urine samples and non-consecutive dietary assessments (two 24-hour recalls, 8-15 days apart) from 94 participants were included in the present study. Following a salt-assisted matrix extraction, urine samples were analyzed using LC-MS/MS for the simultaneous determination of ZEN, α-ZEL, β-ZEL, α-ZAL, β-ZAL, ZAN and ZEN14GlcA. ZEN and ZEN-14-GlcA were detected in 52% (36/69) and 14% (10/69) of the analyzed samples, with a mean concentration of 1.2 and 6.9 µg/L, respectively. The metabolites α-ZEL, β-ZEL, α-ZAL, β-ZAL, ZAN were not detected in the urine samples. Considering the 24h-urinary volume, the mean dietary excretion of ZEN and ZEN-14-GlcA was 1.5 and 7.8 µg/day, respectively. These data will allow the determination of Probably Daily Intake of zearalenone with more accuracy since it reflects the internal exposure of participants.pt_PT
dc.description.sponsorshipThis research was performed under CESAM (UID/AMB/50017/2013) funded by the Fundação para a Ciência e Tecnologia (FCT), Portugal. The authors also acknowledge the support of MYTOX-SOUTH network.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/5895
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectToxicologiapt_PT
dc.subjectAvaliação de Riscopt_PT
dc.subjectSaúde Humanapt_PT
dc.subjectMicotoxinaspt_PT
dc.subjectBiomonitorizaçãopt_PT
dc.subjectZearalenonept_PT
dc.subjectMycotoxinspt_PT
dc.subjectPortuguese Population
dc.subjectPortugal
dc.titleAre Portuguese population exposed to Zearalenone? A human biomonitoring study as a contribution to the risk assessment of an endocrine disruptorpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.title1st Workshop on Human Biomonitoring in Portugal, INSA, 11 maio 2018pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublication1d7db62a-6440-4ccb-a5cc-c3f76c8585b3
relation.isProjectOfPublication.latestForDiscovery1d7db62a-6440-4ccb-a5cc-c3f76c8585b3

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