An integrative system biology approach to delineate complex genotype-phenotype associations in Autism Spectrum Disorder

Asif, Muhammad; Couto, Francisco M.; Vicente, Astrid M.

http://hdl.handle.net/10400.18/5637

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Authors

Asif, Muhammad

Couto, Francisco M.

Vicente, Astrid M.

Abstract(s)

Objectives: To identify clinically similar subgroups of individuals with ASD [To reduce ASD heterogeneous phenotype]; To find biological processes disrupted by rare CNVs targeting brain genes in ASD subjects [To maximize the reproducibility with other data sets]; To train a machine learning classifier for the clinical prediction of disease progression from genetic information in very young children [To facilitate clinical doctors in diagnosis]