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Tracking SARS-CoV-2 lineage B.1.1.7 dissemination: insights from nationwide spike gene target failure (SGTF) and spike gene late detection (SGTL) data, Portugal, week 49 2020 to week 3 2021

2021-03Journal article Open access
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dc.contributor.authorBorges, Vítor
dc.contributor.authorSousa, Carlos
dc.contributor.authorMenezes, Luís
dc.contributor.authorGonçalves, António Maia
dc.contributor.authorPicão, Miguel
dc.contributor.authorAlmeida, José Pedro
dc.contributor.authorVieita, Margarida
dc.contributor.authorSantos, Rafael
dc.contributor.authorSilva, Ana Rita
dc.contributor.authorCosta, Mariana
dc.contributor.authorCarneiro, Luís
dc.contributor.authorCasaca, Pedro
dc.contributor.authorPinto-Leite, Pedro
dc.contributor.authorPeralta-Santos, André
dc.contributor.authorIsidro, Joana
dc.contributor.authorDuarte, Sílvia
dc.contributor.authorVieira, Luís
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorSilva, Susana
dc.contributor.authorNunes, Baltazar
dc.contributor.authorGomes, João P.
dc.date.accessioned2022-07-04T16:38:50Z
dc.date.available2022-07-04T16:38:50Z
dc.date.issued2021-03
dc.description.abstractWe show that the SARS-CoV-2 B.1.1.7 lineage is highly disseminated in Portugal, with the odds of B.1.1.7 proportion increasing at an estimated 89% (95% confidence interval: 83-95%) per week until week 3 2021. RT-PCR spike gene target late detection (SGTL) can constitute a useful surrogate to track B.1.1.7 spread, besides the spike gene target failure (SGTF) proxy. SGTL/SGTF samples were associated with statistically significant higher viral loads, but not with substantial shift in age distribution compared to non-SGTF/SGTL cases.pt_PT
dc.description.sponsorshipThis study is partially co-funded by Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica (234_596874175) on behalf of the Research 4 COVID-19 call. Some infrastructural resources used in this study come from GenomePT project (POCI-01-0145- FEDER-022184), supported by COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by Fundação para a Ciência e a Tecnologia (FCT).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEuro Surveill. 2021 Mar;26(10):2100131. doi: 10.2807/1560-7917.ES.2021.26.10.2100130pt_PT
dc.identifier.doi10.2807/1560-7917.ES.2021.26.10.2100130pt_PT
dc.identifier.issn1560-7917
dc.identifier.urihttp://hdl.handle.net/10400.18/8056
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherEuropean Centre for Disease Prevention and Controlpt_PT
dc.relation.publisherversionhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2021.26.10.2100130pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectB.1.1.7 Lineagept_PT
dc.subjectRT-PCRpt_PT
dc.subjectSARS-CoV-2pt_PT
dc.subjectGenome Sequencingpt_PT
dc.subjectLaboratory Surveillancept_PT
dc.subjectSpike Gene Target Failure (SGTF)pt_PT
dc.subjectSpike Gene Target Late Detection (SGTL)pt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.subjectPortugalpt_PT
dc.titleTracking SARS-CoV-2 lineage B.1.1.7 dissemination: insights from nationwide spike gene target failure (SGTF) and spike gene late detection (SGTL) data, Portugal, week 49 2020 to week 3 2021pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue10pt_PT
oaire.citation.startPage2100131pt_PT
oaire.citation.titleEurosurveillancept_PT
oaire.citation.volume26pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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