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Publicação
Tracking SARS-CoV-2 lineage B.1.1.7 dissemination: insights from nationwide spike gene target failure (SGTF) and spike gene late detection (SGTL) data, Portugal, week 49 2020 to week 3 2021
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Orientador(es)
Resumo(s)
We show that the SARS-CoV-2 B.1.1.7 lineage is highly disseminated in Portugal, with the odds of B.1.1.7 proportion increasing at an estimated 89% (95% confidence interval: 83-95%) per week until week 3 2021. RT-PCR spike gene target late detection (SGTL) can constitute a useful surrogate to track B.1.1.7 spread, besides the spike gene target failure (SGTF) proxy. SGTL/SGTF samples were associated with statistically significant higher viral loads, but not with substantial shift in age distribution compared to non-SGTF/SGTL cases.
Descrição
Palavras-chave
B.1.1.7 Lineage RT-PCR SARS-CoV-2 Genome Sequencing Laboratory Surveillance Spike Gene Target Failure (SGTF) Spike Gene Target Late Detection (SGTL) Infecções Respiratórias Estados de Saúde e de Doença Portugal
Contexto Educativo
Citação
Euro Surveill. 2021 Mar;26(10):2100131. doi: 10.2807/1560-7917.ES.2021.26.10.2100130
Editora
European Centre for Disease Prevention and Control