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Publicação
A Shared Perspective on in Vitro and in Vivo Models to Assay Intestinal Transepithelial Transport of Food Compounds
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Orientador(es)
Resumo(s)
Assessing nutrient bioavailability is complex, as the process involves multiple digestion steps, several cellular environments, and regulatory-metabolic mechanisms. Several in vitro models of different physiological relevance are used to study nutrient absorption, providing significant challenges in data evaluation. However, such in vitro models are needed for mechanistic studies as well as to screen for biological functionality of the food structures designed. This collaborative work aims to put into perspective the wide-range of models to assay the permeability of food compounds considering the particular nature of the different molecules, and, where possible, in vivo data are provided for comparison.
Descrição
Review
Palavras-chave
Food Compounds Intestines Nutrient Bioavailability Transepithelial Transport Transporte Transepitelial Intestino Toxicologia Segurança Alimentar
Contexto Educativo
Citação
J Agric Food Chem. 2023 Dec 13;71(49):19265-19276. doi: 10.1021/acs.jafc.3c05479. Epub 2023 Nov 30. Review
Editora
ACS Publications