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A Shared Perspective on in Vitro and in Vivo Models to Assay Intestinal Transepithelial Transport of Food Compounds

2023-11-30Journal article Restricted access
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dc.contributor.authorHevia, Arancha
dc.contributor.authorRuas-Madiedo, Patricia
dc.contributor.authorFaria, Miguel Angelo
dc.contributor.authorPetit, Valérie
dc.contributor.authorAlves, Bruna
dc.contributor.authorAlvito, Paula
dc.contributor.authorArranz, Elena
dc.contributor.authorBastiaan-Net, Shanna
dc.contributor.authorCorredig, Milena
dc.contributor.authorDijk, Wieneke
dc.contributor.authorDupont, Didier
dc.contributor.authorGiblin, Linda
dc.contributor.authorGraf, Brigitte Anna
dc.contributor.authorKondrashina, Alina
dc.contributor.authorRamos, Helena
dc.contributor.authorRuiz, Lorena
dc.contributor.authorSantos-Hernández, Marta
dc.contributor.authorSoriano-Romaní, Laura
dc.contributor.authorTomás-Cobos, Lidia
dc.contributor.authorVivanco-Maroto, Santiaga María
dc.contributor.authorRecio, Isidra
dc.contributor.authorMiralles, Beatriz
dc.date.accessioned2024-01-22T15:56:40Z
dc.date.available2024-01-22T15:56:40Z
dc.date.issued2023-11-30
dc.descriptionReviewpt_PT
dc.description.abstractAssessing nutrient bioavailability is complex, as the process involves multiple digestion steps, several cellular environments, and regulatory-metabolic mechanisms. Several in vitro models of different physiological relevance are used to study nutrient absorption, providing significant challenges in data evaluation. However, such in vitro models are needed for mechanistic studies as well as to screen for biological functionality of the food structures designed. This collaborative work aims to put into perspective the wide-range of models to assay the permeability of food compounds considering the particular nature of the different molecules, and, where possible, in vivo data are provided for comparison.pt_PT
dc.description.sponsorshipM.A.F. thanks FCT (Fundação para a Ciência e Tecnologia) for funding through program DL 57/2016 and the project DIETxPOSOME (PTDC/SAU-NUT/6061/2020). P.A. acknowledges CESAM (UIDP/50017/2020+UIDB/50017/ 2020+LA/P/0094/2020). Thanks are due to FCT/MCTES through national funds EarlyMyco (PTDC/MED-TOX/28762/2017). S.B.-N. acknowledges the financial support by the Dutch Ministry of Agriculture, Nature and Food Quality via the “Healthy and Safe Food System (KB-37)” knowledge base program (grand no. KB-37-001-007). P.R.-M. acknowl edges the financial support to the project PID2021-127362OB I00, funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe” (European Union). B.M. acknowledges the financial support by project I-link22018 financed by CSIC and PID2019-107663RB-I00 and PCD2022- 133489-IOO funded b y MCIN/AEI/10.13039/ 501100011033, the last counting with funds from EU “NextGeneration EU”/PRTR. This work has been conducted within the frame of the INFOGEST International Network funded by INRAE.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Agric Food Chem. 2023 Dec 13;71(49):19265-19276. doi: 10.1021/acs.jafc.3c05479. Epub 2023 Nov 30. Reviewpt_PT
dc.identifier.doi10.1021/acs.jafc.3c05479pt_PT
dc.identifier.issn0021-8561
dc.identifier.urihttp://hdl.handle.net/10400.18/8948
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherACS Publicationspt_PT
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acs.jafc.3c05479pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFood Compoundspt_PT
dc.subjectIntestinespt_PT
dc.subjectNutrient Bioavailabilitypt_PT
dc.subjectTransepithelial Transportpt_PT
dc.subjectTransporte Transepitelialpt_PT
dc.subjectIntestinopt_PT
dc.subjectToxicologiapt_PT
dc.subjectSegurança Alimentarpt_PT
dc.titleA Shared Perspective on in Vitro and in Vivo Models to Assay Intestinal Transepithelial Transport of Food Compoundspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2020/PTDC%2FSAU-NUT%2F6061%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0094%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-TOX%2F28762%2F2017/PT
oaire.citation.endPage19276pt_PT
oaire.citation.issue49pt_PT
oaire.citation.startPage19265pt_PT
oaire.citation.titleJournal of Agricultural and Food Chemistrypt_PT
oaire.citation.volume71pt_PT
oaire.fundingStreamConcurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2020
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com a política editorial da revista.pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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