Repository logo
 
Publication

Tuberculin skin test and predictive host factors for false‐negative results in patients with pulmonary and extrapulmonary tuberculosis

2020-06Journal article Restricted access
Simple item page
dc.contributor.authorAlmeida Santos, João
dc.contributor.authorDuarte, Raquel
dc.contributor.authorNunes, Carla
dc.date.accessioned2021-03-31T16:44:03Z
dc.date.available2021-03-31T16:44:03Z
dc.date.issued2020-06
dc.description.abstractIntroduction: Tuberculin skin test (TST) has been the standard test for screening for Mycobacterium tuberculosis infection for decades. Identifying persons with latent tuberculosis infection (LTBI) is crucial, as they constitute a reservoir that sustains the global tuberculosis (TB) epidemic. However, different factors, such as HIV infection, can lower the sensitivity of the test. Objectives: The aim of this study was to determine the TST sensitivity in active TB patients and to ascertain risk factors that could be associated with false-negative results. Methods: Retrospective cohort study of all active TB notifications with a TST result (n = 8833), from 2008 to 2015. TST results were interpreted using a 5 mm and 10 mm cutoff. Bivariate and multivariate logistic regression analysis were used to evaluate the association of sociodemographic and clinical factors with false-negative TST results and to develop predictive risk models. Results: TST presented an overall sensitivity of 63.8% (5 mm) and 56.1% (10 mm). HIV infection was the risk factor with the strongest association with false-negative results (aOR 4.65-5 mm; aOR 5.05-10 mm). Other factors such as chronic renal failure (CRF) (aOR 1.55-5 mm; aOR 1.73-10 mm), alcohol abuse (aOR 1.52-5 mm; aOR 1.31-10 mm), drug abuse (aOR 1.90-5 mm; aOR 1.76-10 mm) or age ≥65 years (OR 1.69-5 mm and 10 mm) were also associated with a probability of false-negative results. Conclusion: These results highlight the importance of knowing which factors influence TST results, such as HIV status, substance abuse or age, thus improving its usefulness as a screening method for LTBI.pt_PT
dc.description.sponsorshipFundação para a Ciência e a Tecnologia, Grant/Award Number: PTDC/SAUPUB/31346/2017pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationClin Respir J. 2020 Jun;14(6):541-548. doi: 10.1111/crj.13166. Epub 2020 Feb 28.pt_PT
dc.identifier.doi10.1111/crj.13166pt_PT
dc.identifier.issn1752-6981
dc.identifier.urihttp://hdl.handle.net/10400.18/7617
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationPTDC/SAUPUB/31346/2017pt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/abs/10.1111/crj.13166pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAdolescentpt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectAged, 80 and overpt_PT
dc.subjectAlcoholismpt_PT
dc.subjectComorbiditypt_PT
dc.subjectFalse Negative Reactionspt_PT
dc.subjectFemalept_PT
dc.subjectHIV Infectionspt_PT
dc.subjectHumanspt_PT
dc.subjectKidney Failure, Chronicpt_PT
dc.subjectLatent Tuberculosispt_PT
dc.subjectMalept_PT
dc.subjectMass Screeningpt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPredictive Value of Testspt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectRisk Factorspt_PT
dc.subjectSensitivity and Specificitypt_PT
dc.subjectSubstance-Related Disorderspt_PT
dc.subjectTuberculin Testpt_PT
dc.subjectTuberculosispt_PT
dc.subjectYoung Adultpt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.titleTuberculin skin test and predictive host factors for false‐negative results in patients with pulmonary and extrapulmonary tuberculosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage548pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage541pt_PT
oaire.citation.titleClinical Respiratory Journalpt_PT
oaire.citation.volume14pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
12_Tuberculin.pdf
Size:
319.49 KB
Format:
Adobe Portable Document Format
Download

Collections

DDI - Artigos em revistas internacionais