Logo do repositório
 
Publicação

First identification and molecular characterization of CTX-M-15 extended-spectrum β-lactamase and OXA-9 β-lactamase in Haemophilus influenzae in the Iberian Peninsula

2026-01-30Artigo científico Acesso aberto
Ver registo simples
datacite.subject.fosCiências Médicas::Ciências da Saúde
dc.contributor.authorGonzález-Díaz, A.
dc.contributor.authorPinto, M.
dc.contributor.authorCadenas-Jiménez, I.
dc.contributor.authorDuarte, S.
dc.contributor.authorArdanuy, C.
dc.contributor.authorRibeiro, M.M.
dc.contributor.authorMartí, S.
dc.contributor.authorBajanca-Lavado, P.
dc.date.accessioned2026-09-24T17:30:12Z
dc.date.available2026-09-24T17:30:12Z
dc.date.issued2026-01-30
dc.description.abstractWe describe, for the first time, the presence and characterization of CTX-M-15 and OXA-9 in two Haemophilus influenzae strains: PTHi-14525 (CTX-M-15) from Portugal and HUB-HI042681 (OXA-9) from Spain. Multidrug-resistant PTHi-14525 carried blaCTX-M-15 (two copies) and blaTEM-1 in an ICEHpaHUB5-like element. HUB-HI042681, resistant to β-lactams and aminoglycosides, carried a novel ICEHinHUB1. These findings highlight the genomic plasticity and expanded resistome of H. influenzae, raising concerns about treatment and emphasizing the need for continuous genomic surveillance.eng
dc.description.sponsorshipThis study was co-funded by the European Union project “Sustainable use and integration of enhanced infrastructure into routine genome-based surveillance and outbreak investigation activities in Portugal”—GENEO (Project no. 101113460) on behalf of the EU4H program (EU4H-2022-DGA-MS-IBA-01-02). The National Institute of Health Doutor Ricardo Jorge also supports Haemophilus influenzae surveillance activities. Additional funding was provided by the Instituto de Salud Carlos III through the Projects from the Fondo de Investigaciones Sanitarias (PI22/00257 to S.M.) and the Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES; CB06/06/0037). The European Regional Development Fund and the European Social Fund Plus (ERDF/ESF; "Investing in your future") also provided financial support and the CERCA Program/Generalitat de Catalunya provided institutional support.
dc.identifier.citationAntimicrob Agents Chemother. 2026 Mar 4;70(3):e0164925. doi: 10.1128/aac.01649-25. Epub 2026 Jan 30
dc.identifier.doi10.1128/aac.01649-25
dc.identifier.issn0066-4804
dc.identifier.pmid41616261
dc.identifier.urihttp://hdl.handle.net/10400.18/11339
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAmerican Society for Microbiology
dc.relation.hasversionhttps://journals.asm.org/doi/10.1128/aac.01649-25
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectHaemophilus influenzae
dc.subjectMultidrug Resistance
dc.subjectAntimicrobial Resistance
dc.subjectBeta-lactamase
dc.subjectMobile Elements
dc.subjectWhole-genome Sequencing
dc.subjectCTX-M-15
dc.subjectInfecções Respiratórias
dc.subjectResistência aos Antimicrobianos
dc.titleFirst identification and molecular characterization of CTX-M-15 extended-spectrum β-lactamase and OXA-9 β-lactamase in Haemophilus influenzae in the Iberian Peninsulaeng
dc.typejournal article
dcterms.referenceshttps://journals.asm.org/doi/suppl/10.1128/aac.01649-25/suppl_file/aac.01649-25-s0001.xlsx
dspace.entity.typePublication
oaire.citation.issue3
oaire.citation.startPagee0164925
oaire.citation.titleAntimicrobial Agents and Chemotherapy
oaire.citation.volume70
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
First identification and molecular characterization of CTX-M-15 extended-spectrum beta-lactamase and OXA-9 beta-lactamase in Haemophilus influenzae in the Iberian Peninsula.pdf
Tamanho:
570.78 KB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
4.03 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

DDI - Artigos em revistas internacionais
INSA - Artigos em revistas internacionais