First identification and molecular characterization of CTX-M-15 extended-spectrum β-lactamase and OXA-9 β-lactamase in Haemophilus influenzae in the Iberian Peninsula

González-Díaz, A.; Pinto, M.; Cadenas-Jiménez, I.; Duarte, S.; Ardanuy, C.; Ribeiro, M.M.; Martí, S.; Bajanca-Lavado, P.

http://hdl.handle.net/10400.18/11339

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First identification and molecular characterization of CTX-M-15 extended-spectrum beta-lactamase and OXA-9 beta-lactamase in Haemophilus influenzae in the Iberian Peninsula.pdf		570.78 KB	Adobe PDF	Ver/Abrir

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Resumo(s)

We describe, for the first time, the presence and characterization of CTX-M-15 and OXA-9 in two Haemophilus influenzae strains: PTHi-14525 (CTX-M-15) from Portugal and HUB-HI042681 (OXA-9) from Spain. Multidrug-resistant PTHi-14525 carried blaCTX-M-15 (two copies) and blaTEM-1 in an ICEHpaHUB5-like element. HUB-HI042681, resistant to β-lactams and aminoglycosides, carried a novel ICEHinHUB1. These findings highlight the genomic plasticity and expanded resistome of H. influenzae, raising concerns about treatment and emphasizing the need for continuous genomic surveillance.

Palavras-chave

Haemophilus influenzae Multidrug Resistance Antimicrobial Resistance Beta-lactamase Mobile Elements Whole-genome Sequencing CTX-M-15 Infecções Respiratórias Resistência aos Antimicrobianos

URI

http://hdl.handle.net/10400.18/11339

Citação

Antimicrob Agents Chemother. 2026 Mar 4;70(3):e0164925. doi: 10.1128/aac.01649-25. Epub 2026 Jan 30

Editora

American Society for Microbiology

DOI

10.1128/aac.01649-25

Coleções

DDI - Artigos em revistas internacionais
INSA - Artigos em revistas internacionais

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cclicense-by-nc-nd

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